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Details for Product No. ABIN968129

Heme Oxygenase (Decycling) 1 (HMOX1) (AA 150-286) antibody

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HO1, HO-1, Hmox, Hemox, Hsp32, D8Wsu38e, Ho1, Heox, Ho-1, HEOXG, hsp32, Hmox1, HMOX1D, HSP32, bK286B10, HMOX1, MGC132176, wu:fc27c04, zgc:65984, ARABIDOPSIS THALIANA HEME OXYGENASE 1, ATHO1, F18A8.4,  ... show more
»Alternatives AA 150-286
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 4 references available
Catalog no. ABIN968129
Quantity 50 µg
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Immunogen Human Heme Oxygenase 1 (HO-1)
Clone 23
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Heme Oxygenase 1
Background Heme oxygenases 1 and 2 (HO-1, HO-2) cleave the heme molecule, resulting in the production of carbon monoxide (CO) and biliverdin. HO-1 is a 288 amino acid monooxygenase with a molecular weight of 32 kDa. While HO-2 is constitutively expressed in tissues, HO-1 is rapidly induced by several stimuli such as lutathione depletion, hemin, heat shock, heavy metals, oxidative stress, oxidized LDL, anoxia, and endotoxic shock. Similar to nitric oxide (NO), CO activates guanylate cyclase and reduces platelet aggregation. Several conditions that increase NO also induce HO-1 expression and activity. This suggests that NO synthases, Cox-2, and HO-1 are part of a general defense mechanism against stress and pathogen invasion.
Molecular Weight 32 kDa
Research Area Cancer, Atherosclerosis, Alzheimer's Disease
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Yoshida, Biro, Cohen et al.: "Human heme oxygenase cDNA and induction of its mRNA by hemin." in: European journal of biochemistry / FEBS, Vol. 171, Issue 3, pp. 457-61, 1988 (PubMed).

Foresti, Clark, Green et al.: "Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions." in: The Journal of biological chemistry, Vol. 272, Issue 29, pp. 18411-7, 1997 (PubMed).

Ishikawa, Navab, Leitinger et al.: "Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL." in: The Journal of clinical investigation, Vol. 100, Issue 5, pp. 1209-16, 1997 (PubMed).

Suzuki, Ishizaka, Tsukamoto et al.: "Pressurization facilitates adenovirus-mediated gene transfer into vein graft." in: FEBS letters, Vol. 470, Issue 3, pp. 370-4, 2000 (PubMed).

Alternatives for antigen "Heme Oxygenase (Decycling) 1 (HMOX1)", type "Antibodies"
Hosts (78), (37), (1)
Reactivities (86), (56), (40), (24), (21), (19), (14), (12), (5), (5), (4), (2), (2), (1)
Applications (99), (46), (30), (27), (20), (19), (12), (10), (10), (8), (4), (3), (2), (2), (1), (1), (1)
Conjugates (8), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (10), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)