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Heme Oxygenase (Decycling) 1 (HMOX1) (AA 150-286) antibody

Details for Product No. ABIN968130, Supplier: Log in to see
Antigen
  • HMOX1
  • HO1
  • MGC132176
  • wu:fc27c04
  • zgc:65984
  • ARABIDOPSIS THALIANA HEME OXYGENASE 1
  • ATHO1
  • F18A8.4
  • F18A8_4
  • GENOMES UNCOUPLED 2
  • GUN2
  • HEME OXYGENASE
  • HEME OXYGENASE 1
  • HEME OXYGENASE 6
  • HY1
  • HY6
  • PLASTID HEME OXYGENASE
  • REVERSAL OF THE DET PHENOTYPE 4
  • HMOX1D
  • HO-1
  • HSP32
  • bK286B10
  • D8Wsu38e
  • Hemox
  • Hmox
  • Hsp32
  • HEOXG
  • Heox
  • Ho-1
  • Ho1
  • hsp32
  • Hmox1
Epitope
AA 150-286
43
24
21
19
14
12
11
10
9
5
5
5
4
3
3
2
2
2
1
1
1
1
1
1
Reactivity
Human
245
158
139
46
30
28
26
24
23
19
3
2
2
2
Host
Mouse
227
87
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
16
14
5
5
4
4
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
285
138
118
81
70
47
36
24
12
5
3
1
1
Supplier
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Immunogen Human Heme Oxygenase 1 (HO-1) aa. 150-286
Clone 23-Heme Oxygenase 1
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Heme Oxygenase 1 (HMOX1 Antibody Abstract)
Background Heme oxygenases 1 and 2 (HO-1, HO-2) cleave the heme molecule, resulting in the production of carbon monoxide (CO) and biliverdin. HO-1 is a 288 amino acid monooxygenase with a molecular weight of 32 kDa. While HO-2 is constitutively expressed in tissues, HO-1 is rapidly induced by several stimuli such as lutathione depletion, hemin, heat shock, heavy metals, oxidative stress, oxidized LDL, anoxia, and endotoxic shock. Similar to nitric oxide (NO), CO activates guanylate cyclase and reduces platelet aggregation. Several conditions that increase NO also induce HO-1 expression and activity. This suggests that NO synthases, Cox-2, and HO-1 are part of a general defense mechanism against stress and pathogen invasion.
Molecular Weight 32 kDa
Research Area Cancer, Atherosclerosis, Alzheimer's Disease
Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-Heme Oxygenase (Decycling) 1 (HMOX1) (AA 150-286) antibody (ABIN968130) Western blot analysis of Heme Oxygenase 1 on SW13 lysate. Lane 1: 1:250, lane 2: 1:50...
 image for anti-Heme Oxygenase (Decycling) 1 (HMOX1) (AA 150-286) antibody (ABIN968130) HeLa
 image for anti-Heme Oxygenase (Decycling) 1 (HMOX1) (AA 150-286) antibody (ABIN968130) anti-Heme Oxygenase (Decycling) 1 (HMOX1) (AA 150-286) antibody (Image 3)
Western Blotting (WB) image for anti-Heme Oxygenase (Decycling) 1 (HMOX1) (AA 150-286) antibody (ABIN968130) anti-Heme Oxygenase (Decycling) 1 (HMOX1) (AA 150-286) antibody (Image 4)
Product cited in: Suzuki, Ishizaka, Tsukamoto et al.: "Pressurization facilitates adenovirus-mediated gene transfer into vein graft." in: FEBS letters, Vol. 470, Issue 3, pp. 370-4, 2000 (PubMed).

Ishikawa, Navab, Leitinger et al.: "Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL." in: The Journal of clinical investigation, Vol. 100, Issue 5, pp. 1209-16, 1997 (PubMed).

Foresti, Clark, Green et al.: "Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions." in: The Journal of biological chemistry, Vol. 272, Issue 29, pp. 18411-7, 1997 (PubMed).

Yoshida, Biro, Cohen et al.: "Human heme oxygenase cDNA and induction of its mRNA by hemin." in: European journal of biochemistry / FEBS, Vol. 171, Issue 3, pp. 457-61, 1988 (PubMed).