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Details for Product No. ABIN968146

Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 369-520) antibody

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Antigen
Synonyms SLP76, SLP-76, AI323664, BB161688, twm, Slp76
Epitope
»Alternatives AA 369-520
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 5 references available
Catalog no. ABIN968146
Quantity 50 µg
Price
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Immunogen Human SLP-76
Clone 8
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name SLP-76
Background SLP-76 (SH2 domain-containing Leukocyte Protein) is a tyrosine phosphoprotein that is involved in the TCR mediated intracellular signaling pathway. It may be involved in the signaling pathways of peripheral blood leukocytes, thymic/splenic cells, and in human T, B, and monocytic cell lines. SLP-76 consists of several motifs that signify its importance in protein-protein interactions involved in intracellular signaling pathways, such as the SH2 domain in the C-terminus, the amino-terminus three 17-amino acid repeats with conserved tyrosine and acidic residues (DYE(S/P)P), and a proline rich region. SLP-76 has been shown to associate with Grb2, PLC-gamma, SLAP-130, and Vav-all of which are part of the signaling cascade in T cells. ZAP-70 appears to phosphorylate SLP-76, allowing phosphorylated Vav to bind and, together the SLP-76/Vav complex, cooperatively stimulates NF-AT and IL-2 gene activation. Overexpression of SLP-76 has been reported to increase the TCR-mediated transcription of the IL-2 gene. Furthermore, SHP-1 associates with SLP-76 in normal splenic B cells which suggests a role for SLP-76 in BCR signaling.
Synonyms: SH2 domain-containing Leukocyte Protein
Molecular Weight 76 kDa
Research Area Signaling
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Jackman, Motto, Sun et al.: "Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells." in: The Journal of biological chemistry, Vol. 270, Issue 13, pp. 7029-32, 1995 (PubMed).

Wu, Motto, Koretzky et al.: "Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation." in: Immunity, Vol. 4, Issue 6, pp. 593-602, 1996 (PubMed).

Tuosto, Michel, Acuto: "p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells." in: The Journal of experimental medicine, Vol. 184, Issue 3, pp. 1161-6, 1997 (PubMed).

Zhang, Trible, Zhu et al.: "Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling." in: The Journal of biological chemistry, Vol. 275, Issue 30, pp. 23355-61, 2000 (PubMed).

Harder, Kuhn: "Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies." in: The Journal of cell biology, Vol. 151, Issue 2, pp. 199-208, 2000 (PubMed).

Alternatives for antigen "Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2)", type "Antibodies"
Hosts (74), (25), (10), (2)
Reactivities (108), (42), (33), (20), (14), (14)
Applications (81), (36), (30), (25), (18), (10), (7), (2), (2), (2), (1), (1)
Conjugates (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (14), (12), (12), (8), (7), (6), (3), (2), (1), (1)
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