anti-RANBP1 antibody (RAN Binding Protein 1) (AA 28-163)

Details for Product anti-RANBP1 Antibody No. ABIN968158
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Synonyms MGC64314, zeh1094, zgc:85649, hm:zeh1094, wu:fa96a09, wu:fj39g07, HTF9A, Htf9a
AA 28-163
(18), (4), (2), (2), (2), (1), (1), (1), (1)
(47), (17), (15), (3)
(31), (17)
Clonality (Clone)
Monoclonal ()
This RANBP1 antibody is un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(35), (13), (10), (9), (6), (3), (2), (2), (1)
Pubmed 3 references available
Quantity 50 μg
Shipping to United States ( )
Immunogen Human RanBP1 aa. 28-163
Clone 35-RanBP1
Isotype IgG2a
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name RanBP1 (RANBP1 Antibody Abstract)
Background Ran is a highly conserved GTPase that is ubiquitously expressed. Ran has been implicated in a number of cellular processes such as the initiation of DNA replication, entry into and exit from mitosis, and in nuclear RNA and protein transport through the nuclear pore complex. A number of Ran binding proteins have been identified. One of the smaller proteins identified is a 29kDa cytosolic molecule known as RanBP1. The GTP-bound state of Ran is stabilized through its binding to RanBP1. In addition, RanBP1 appears to regulate the activity of Ran-GAP1 (Ran-GTPase activating protein) by increasing GTP hydrolysis. RanBP1 also inhibits the function of the guanine nucleotide exchange factor RCC1 (regulator of chromosome condensation). Therefore, RanBP1 is responsible for the GTP-bound state of Ran and the increased GTP hydrolysis of Ran GTP.
Molecular Weight 29 kDa
Research Area Chromatin and Nuclear Signaling, DNA/RNA

Related Products: ABIN967389, ABIN968587

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-RANBP1 antibody (RAN Binding Protein 1) (AA 28-163) (ABIN968158) Western blot analysis of RanBP1 on HepG2 lysate. Lane 1: 1:250, lane 2: 1:500, lane 3...
Immunofluorescence (IF) image for anti-RANBP1 antibody (RAN Binding Protein 1) (AA 28-163) (ABIN968158) Immunofluorescence staining of Human Fibroblast cells.
Image no. 3 for anti-RANBP1 antibody (RAN Binding Protein 1) (AA 28-163) (ABIN968158) anti-RAN Binding Protein 1 (RANBP1) (AA 28-163) antibody (Image 3)
Western Blotting (WB) image for anti-RANBP1 antibody (RAN Binding Protein 1) (AA 28-163) (ABIN968158) anti-RAN Binding Protein 1 (RANBP1) (AA 28-163) antibody (Image 4)
Product cited in: Chi, Adam, Visser et al.: "RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import." in: The Journal of cell biology, Vol. 135, Issue 3, pp. 559-69, 1996 (PubMed).

Hayashi, Yokoyama, Seki et al.: "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4." in: Molecular & general genetics : MGG, Vol. 247, Issue 6, pp. 661-9, 1995 (PubMed).

Background publications Bischoff, Krebber, Smirnova et al.: "Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1." in: The EMBO journal, Vol. 14, Issue 4, pp. 705-15, 1995 (PubMed).

Catalog No. ABIN968158
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