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Details for Product No. ABIN968158

RAN Binding Protein 1 (RANBP1) (AA 28-163) antibody

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Antigen
Synonyms HTF9A, Htf9a, MGC64314, ranbp2, MGC76028, zeh1094, zgc:85649, hm:zeh1094, wu:fa96a09, wu:fj39g07
Epitope
»Alternatives AA 28-163
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN968158
Quantity 50 µg
Price
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Immunogen Human RanBP1
Clone G52C7-1
Isotype IgG2a
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name RanBP1
Background Ran is a highly conserved GTPase that is ubiquitously expressed. Ran has been implicated in a number of cellular processes such as the initiation of DNA replication, entry into and exit from mitosis, and in nuclear RNA and protein transport through the nuclear pore complex. A number of Ran binding proteins have been identified. One of the smaller proteins identified is a 29kDa cytosolic molecule known as RanBP1. The GTP-bound state of Ran is stabilized through its binding to RanBP1. In addition, RanBP1 appears to regulate the activity of Ran-GAP1 (Ran-GTPase activating protein) by increasing GTP hydrolysis. RanBP1 also inhibits the function of the guanine nucleotide exchange factor RCC1 (regulator of chromosome condensation). Therefore, RanBP1 is responsible for the GTP-bound state of Ran and the increased GTP hydrolysis of Ran GTP.
Molecular Weight 29 kDa
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Comment

Related Products: ABIN967389, ABIN968587

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Hayashi, Yokoyama, Seki et al.: "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4." in: Molecular & general genetics : MGG, Vol. 247, Issue 6, pp. 661-9, 1995 (PubMed).

Bischoff, Krebber, Smirnova et al.: "Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1." in: The EMBO journal, Vol. 14, Issue 4, pp. 705-15, 1995 (PubMed).

Chi, Adam, Visser et al.: "RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import." in: The Journal of cell biology, Vol. 135, Issue 3, pp. 559-69, 1996 (PubMed).

Alternatives for antigen "RAN Binding Protein 1 (RANBP1)", type "Antibodies"
Hosts (21), (9)
Reactivities (28), (15), (14), (14), (12), (12), (12), (12), (12), (1), (1), (1)
Applications (19), (11), (10), (4), (3), (3), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (2), (1), (1), (1)
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