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Details for Product No. ABIN968177

Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA) (AA 15-123) antibody

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Antigen
Synonyms NACP, PARK1, PARK4, PD1
Epitope
»Alternatives AA 15-123
Reactivity
»Alternatives Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
Pubmed 5 references available
Catalog no. ABIN968177
Quantity 150 µg
Price
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Immunogen Rat Synuclein-1
Clone BF12
Isotype IgG1
Cross-Reactivity Human, Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name alpha -Synuclein
Background Synuclein cDNA was isolated from Torpedo californica and found to encode a 143 amino acid neuron-specific protein. In addition, a rat brain cDNA library yielded several clones that encode different proteins with homology to Torpedo Synuclein. A 140 amino acid protein in rat is referred to as Synuclein-1. In situ hybridization shows synuclein mRNAs in discrete areas of rat brain, notably the hippocampus. In humans, two synuclein proteins of 140 and 134 amino acids were sequenced that exhibit a high degree of homology with each other (61% identity) and with previously described Synuclein proteins. The 140 amino acid protein (alpha-Synuclein) is the human homologue of rat Synuclein-1 and is identical to the non-amyloid-beta component precursor (NACP), a presynaptic protein involved in amyloidogenesis in Alzheimer's disease (AD). The 134 amino acid protein (beta-Synuclein) is the human homologue of bovine phosphoneuroprotein. These proteins are expressed in brain, primarily in presynaptic nerve terminals. Although the exact function of the Synucleins has not been determined, they have been linked to the prominent neurodegenerative disorders AD and Parkinson's disease. This antibody is routinely tested by western blot analysis.
Molecular Weight 19 kDa
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Maroteaux, Campanelli, Scheller: "Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 8, Issue 8, pp. 2804-15, 1988 (PubMed).

Jo, McLaurin, Yip et al.: "alpha-Synuclein membrane interactions and lipid specificity." in: The Journal of biological chemistry, Vol. 275, Issue 44, pp. 34328-34, 2000 (PubMed).

van der Putten, Wiederhold, Probst et al.: "Neuropathology in mice expressing human alpha-synuclein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 16, pp. 6021-9, 2000 (PubMed).

Ostrerova-Golts, Petrucelli, Hardy et al.: "The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 16, pp. 6048-54, 2000 (PubMed).

Liu, Fallon, Lashuel et al.: "The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility." in: Cell, Vol. 111, Issue 2, pp. 209-18, 2002 (PubMed).

Alternatives for antigen "Synuclein, alpha (Non A4 Component of Amyloid Precursor) (SNCA)", type "Antibodies"
Hosts (252), (93), (16), (13), (1)
Reactivities (357), (171), (148), (91), (87), (78), (24), (24), (2), (1), (1), (1)
Applications (237), (135), (93), (80), (60), (49), (22), (17), (13), (8), (6), (3), (2), (1), (1), (1)
Conjugates (11), (9), (9), (8), (8), (8), (8), (8), (8), (8), (8)
Epitopes (36), (31), (25), (23), (20), (12), (9), (8), (8), (6), (6), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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