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Filamin C, gamma (FLNC) (AA 2492-2647) antibody

Details for Product No. ABIN968182
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Antigen
Synonyms ABP-280, ABP280A, ABPA, ABPL, FLN2, MFM5, MPD4, Fln2, 1110055E19Rik
Epitope
AA 2492-2647
(2), (1), (1), (1)
Reactivity
Human
(17), (13), (12), (12), (12), (12)
Host
Mouse
(16), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(10), (8), (6), (5), (2), (2)
Pubmed 5 references available
Quantity 50 µg
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Catalog No. ABIN968182
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Immunogen Human ABP-280
Clone 5
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name ABP-280
Background ABP-280, also known as non-muscle Filamin, is a homodimeric actin-binding protein often found with membrane glycoproteins where it plays a role in cell motility. The human ABP-280 gene, mapped at the chromosomal region Xq28, consists of 47 exons extending approximately 26 kb. The protein has an actin-binding domain at its NH2-terminal region, a central rod-like domain, and a C-terminal domain responsible for the dimerization properties of ABP-280. ABP-280 is ubiquitously expressed and appears also to interact with the beta2-integrin subunit of CD18 in leukocytes. Furthermore, the active SEK-1, an immediate activator of stress-activated protein kinases, interacts with ABP-280. Interestingly, cells with an interaction-deficient ABP-280 failed to respond to the TNFalpha-dependent SEK-1 activation. Thus, ABP-280 is an important regulator of the stress-activated protein kinase signaling pathway.
Synonyms: non-muscle Filamin
Molecular Weight 280 kDa
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Filamin C, gamma (FLNC) (AA 2492-2647) antibody Western blot analysis of ABP-280 on a human endothelial cell lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti-human ABP-280 antibody.
anti-Filamin C, gamma (FLNC) (AA 2492-2647) antibody (2) anti-Filamin C, gamma (FLNC) (AA 2492-2647) antibody (Image 2)
Product cited in: Faĭtelberg: "[Neural regulation of the absorptive activity of the gastrointestinal tract]." in: Uspekhi fiziologicheskikh nauk, Vol. 21, Issue 2, pp. 71-82, 1990 (PubMed).

Gorlin, Yamin, Egan et al.: "Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring." in: The Journal of cell biology, Vol. 111, Issue 3, pp. 1089-105, 1990 (PubMed).

Sharma, Ezzell, Arnaout: "Direct interaction of filamin (ABP-280) with the beta 2-integrin subunit CD18." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 7, pp. 3461-70, 1995 (PubMed).

Price, Caprette, Gomer: "Different temporal patterns of expression result in the same type, amount, and distribution of filamin (ABP) in cardiac and skeletal myofibrils." in: Cell motility and the cytoskeleton, Vol. 27, Issue 3, pp. 248-61, 1994 (PubMed).

Tsuchiya, Iseda, Hino: "Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product." in: Cancer research, Vol. 56, Issue 13, pp. 2881-5, 1996 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN968182
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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