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Details for Product No. ABIN968185

Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1) (AA 109-247) antibody

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Synonyms AMPK, HAMPKb, AU021155, E430008F22, 1300015D22Rik, MGC82489
»Alternatives AA 109-247
»Alternatives Rat (Rattus)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 4 references available
Catalog no. ABIN968185
Quantity 50 µg
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Immunogen Rat AMPK beta
Clone 6G3
Isotype IgG1
Cross-Reactivity Mouse (Murine), Human, Dog (Canine), Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name AMPK-beta
Background AMP activated protein kinase (AMPK) was identified as a result of its phosphorylation and inactivation of lipid metabolism enzymes. However, AMPK also phosphorylates enzymes involved in other metabolic pathways. AMPK is activated by AMPKK (AMPK Kinase)n-mediated phosphorylation in response to intracellular changes in AMP levels. Although rat skeletal muscle AMPK exists as a monomer, active rat liver AMPK is a heterotrimer of alpha (catalytic subunit), beta, and gamma subunits. The catalytic subunit (63 kDa) is structurally and functionally related to the S. cerevisiae SNF1 protein kinase, an enzyme that is required for expression of glucose repressed genes during glucose starvation. AMPK beta (38 kDa) is strongly related to SIP2 (35% identity) and contains a C-terminal region that is very homologous to the SIP1/SIP2/GAL83 ASC domain. AMPK beta has some identity (35%) with SNF4, which is necessary for SNF1 activation. Both AMPK beta and gamma are widely expressed in rat tissues. AMPK beta facilitates the interactions of the alpha and gamma subunits in vitro. Although AMPK beta is clearly necessary for formation of the heterotrimeric complex, there are other probably, yet unknown, roles for this protein.
Synonyms: AMP activated protein kinase
Molecular Weight 38 kDa

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Woods, Cheung, Smith et al.: "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro." in: The Journal of biological chemistry, Vol. 271, Issue 17, pp. 10282-90, 1996 (PubMed).

Michell, Stapleton, Mitchelhill et al.: "Isoform-specific purification and substrate specificity of the 5'-AMP-activated protein kinase." in: The Journal of biological chemistry, Vol. 271, Issue 45, pp. 28445-50, 1996 (PubMed).

Winder, Wilson, Hardie et al.: "Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 82, Issue 1, pp. 219-25, 1997 (PubMed).

Mitchelhill, Michell, House et al.: "Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit." in: The Journal of biological chemistry, Vol. 272, Issue 39, pp. 24475-9, 1997 (PubMed).

Alternatives for antigen "Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1)", type "Antibodies"
Hosts (114), (7)
Reactivities (107), (93), (85), (24), (24), (12)
Applications (91), (65), (35), (30), (24), (7), (4), (3), (2), (1), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (20), (17), (13), (11), (8), (5), (2), (1), (1), (1), (1)