Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Add to Basket
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN968243

Sjogren Syndrome Antigen B (SSB) (AA 179-289) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms SS-B
Epitope
AA 179-289
Reactivity
Human
Host
Mouse
Clonality (Clone) Monoclonal ()
Application
Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN968243
Quantity 150 µg
Price
Contact our Customer Service for availability and price in your country.
Shipping to
Immunogen Human La Protein
Clone DF5
Isotype IgG1
Cross-Reactivity Human, Dog (Canine), Rabbit, Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name La Protein
Background La was first found to bind autoantibodies from individuals with Sjogren's syndrome and systemic lupus erythematosus (SLE). La is a transcription factor for RNA polymerase III (Pol III). It participates in the termination of Pol III-mediated transcription and the recycling of the transcriptional machinery. La associates with the 3' oligo U portion of transcripts generated by Pol III. In some cases, this association protects the message from 3' processing. The association of La and mRNA is mediated by the presence of an N-terminal ribonucleoprotein (RNP) consensus sequence in La. The La protein also binds several small RNAs, such as 7S RNA, 5S RNA, and tRNA, and is thought to be involved in their biogenesis. It is known that histone mRNA is stabilized throughout S Phase and is degraded only at the end of S phase. La protein participates in the stabilization of histone mRNA which results in increased production of histone protein. These data suggest that a major function of La is to protect vital nascent transcripts from premature degradation.
Molecular Weight 47 kDa
Comment

Related Products: ABIN968551, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Chambers, Kenan, Martin et al.: "Genomic structure and amino acid sequence domains of the human La autoantigen." in: The Journal of biological chemistry, Vol. 263, Issue 34, pp. 18043-51, 1989 (PubMed).

McLaren, Caruccio, Ross: "Human La protein: a stabilizer of histone mRNA." in: Molecular and cellular biology, Vol. 17, Issue 6, pp. 3028-36, 1997 (PubMed).

Goodier, Fan, Maraia: "A carboxy-terminal basic region controls RNA polymerase III transcription factor activity of human La protein." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5823-32, 1997 (PubMed).

Beacon