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Fatty Acid Synthase antibody (FASN) (AA 9-202)

Details for Product anti-FASN Antibody No. ABIN968279, Supplier: Login to see New
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Antigen
Synonyms
FASN, fj34h12, wu:fj34h12, Cgl0836, BcDNA:GH07626, BcDNA:gh07626, DM_7295848, Dmel\\CG3523, FAS, Fatty acid synthase, anon-EST:Posey235, anon-EST:Posey43, anon-WO0138581.1, dFAS, fas, OA-519, SDR27X1, ... show more
FASN, fj34h12, wu:fj34h12, Cgl0836, BcDNA:GH07626, BcDNA:gh07626, DM_7295848, Dmel\\CG3523, FAS, Fatty acid synthase, anon-EST:Posey235, anon-EST:Posey43, anon-WO0138581.1, dFAS, fas, OA-519, SDR27X1, A630082H08Rik show less
Alternatives
Epitope
AA 9-202
(15), (14), (13), (12), (8), (8), (7), (6), (6), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
(115), (46), (30), (8), (2), (1), (1), (1)
Host
Mouse
(100), (28), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
This Fatty Acid Synthase antibody is un-conjugated
(3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(98), (45), (32), (30), (20), (15), (15), (11), (8), (7), (2), (2), (1), (1), (1)
Pubmed 3 references available
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Quantity 150 μg
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Immunogen Human Fatty Acid Synthase aa. 9-202
Clone 23-Fatty Acid Synthase
Isotype IgG1
Cross-Reactivity Dog (Canine), Mouse (Murine), Rabbit, Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Fatty Acid Synthase (FASN Antibody Abstract)
Background Fatty acid biosynthesis occurs in all living organisms and provides essential components of biological membranes as well as a form of energy storage. Animal fatty acid synthase (FAS) is a multifunctional enzyme that catalyzes the synthesis of long-chain fatty acids via sequential condensation of two-carbon units from malonyl-CoA, an intermediate derived from the carboxylation of Acetyl-CoA. FAS is a homodimer of a multifunctional subunit protein that contains seven distinct activities and a site for the prosthetic group 4'-phosphopantetheine (acyl carrier protein). These domains are oriented from N-terminus to C-terminus as follows: beta-keto-acyl synthase, acetyl and malonyl transacylases, enoyl reductase, ketoacyl reductase, acyl carrier protein, and thioesterase. Although all domains are found on each subunit, they are only active following the homodimerization of subunits in an antiparallel (head-to-tail) orientation. This juxtaposition and cooperation between domains forms two centers for acyl chain assembly. Alternative substrates and chain-terminating mechanisms allow for the production of a variety of fatty acids with different lengths and structures.
Molecular Weight 265 kDa
Research Area Cancer, Metabolism, Fatty Acids, Enzymes
Pathways AMPK Signaling
Comment

Related Products: ABIN968587, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Fatty Acid Synthase antibody (FASN) (AA 9-202) (ABIN968279) Western blot analysis of Fatty Acid Synthase on HepG2 cell lysate. Lane 1: 1:250, lan...
Immunofluorescence (IF) image for anti-Fatty Acid Synthase antibody (FASN) (AA 9-202) (ABIN968279) Immunofluorescent staining of MDCK cells with anti-FAS antibody.
Image no. 3 for anti-Fatty Acid Synthase antibody (FASN) (AA 9-202) (ABIN968279) anti-Fatty Acid Synthase (FASN) (AA 9-202) antibody (Image 3)
Western Blotting (WB) image for anti-Fatty Acid Synthase antibody (FASN) (AA 9-202) (ABIN968279) anti-Fatty Acid Synthase (FASN) (AA 9-202) antibody (Image 4)
Product cited in: Chirala, Huang, Jayakumar et al.: "Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 11, pp. 5588-93, 1997 (PubMed).

Smith: "The animal fatty acid synthase: one gene, one polypeptide, seven enzymes." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 8, Issue 15, pp. 1248-59, 1995 (PubMed).

Jayakumar, Tai, Huang et al.: "Human fatty acid synthase: properties and molecular cloning." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 19, pp. 8695-9, 1995 (PubMed).

Catalog No. ABIN968279
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