Glutamate Receptor, Ionotropic, delta 2 (GRID2) (AA 665-786) antibody

Details for Product No. ABIN968311
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Antigen
Synonyms GluD2, glurd2, si:rp71-1l7.1, GRID2, B230104L07Rik, GluRdelta2, Lc, Lc, MMS10-AC, Ms10ac, cpr, ho, nmf408, tpr
Epitope
AA 665-786
(2), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(15), (9), (9)
Host
Mouse
(11), (4)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(15), (12), (10), (4), (1)
Pubmed 5 references available
Quantity 50 μg
Options
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Catalog No. ABIN968311
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Immunogen Mouse GluR delta2
Clone CE6
Isotype IgG1
Cross-Reactivity Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name GluR delta 2
Background Glutamate is a major excitatory neurotransmitter of the CNS. The diversity of glutamate is exemplified by two distinct groups of receptors: ionotropic and metabotropic. Ionotroic receptors are ligand-gated cation channels. They can be subdivided into two classes: NMDA and AMPA/kainate receptors. GluR delta2 exhibits only 25% amino acid identity to either ionotropic receptor type. It presents selective and abundant exression in cerebellar Purkinje cells. It is targeted to a subset of Purkinje cell spines and is coexpressed with ionotropic receptors. GluR delta2 is involved in motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression (LTD). The latter is a decrease in the efficacy of the synaptic transmission between parallel fibers and Purkinje neurons and is a cellular basis of motor learning. In fact, mGluR delta2-deficient mice lack LTD. Additionally, an amino acid substitution in transmembrane III of delta2 is responsible for the neurodegeneration seen in Lurcher mice. This substitution is a gain of function mutation that results in disruption of Purkinje membrane potential. Thus, GluR delta2 is an important regulatory component of the Purkinje GluR channel.
Molecular Weight 111 kDa
Comment

Related Products: ABIN967389, ABIN968545

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Glutamate Receptor, Ionotropic, delta 2 (GRID2) (AA 665-786) antibody Western blot analysis of GluR delta2 on rat brain lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of GluR delta2.
anti-Glutamate Receptor, Ionotropic, delta 2 (GRID2) (AA 665-786) antibody (2) Immunofluorescence staining of Rat Neurons
anti-Glutamate Receptor, Ionotropic, delta 2 (GRID2) (AA 665-786) antibody (3) anti-Glutamate Receptor, Ionotropic, delta 2 (GRID2) (AA 665-786) antibody (Image 3)
Product cited in: Araki, Meguro, Kushiya et al.: "Selective expression of the glutamate receptor channel delta 2 subunit in cerebellar Purkinje cells." in: Biochemical and biophysical research communications, Vol. 197, Issue 3, pp. 1267-76, 1994 (PubMed).

Kashiwabuchi, Ikeda, Araki et al.: "Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice." in: Cell, Vol. 81, Issue 2, pp. 245-52, 1995 (PubMed).

Hirano, Kasono, Araki et al.: "Suppression of LTD in cultured Purkinje cells deficient in the glutamate receptor delta 2 subunit." in: Neuroreport, Vol. 6, Issue 3, pp. 524-6, 1995 (PubMed).

Landsend, Amiry-Moghaddam, Matsubara et al.: "Differential localization of delta glutamate receptors in the rat cerebellum: coexpression with AMPA receptors in parallel fiber-spine synapses and absence from climbing fiber-spine synapses." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 17, Issue 2, pp. 834-42, 1997 (PubMed).

Zuo, De Jager, Takahashi et al.: "Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene." in: Nature, Vol. 388, Issue 6644, pp. 769-73, 1997 (PubMed).

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