MST1 antibody (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)) (AA 331-483)

Details for Product anti-MST1 Antibody No. ABIN968344, Supplier: Log in to see
Antigen
  • D3F15S2
  • DNF15S2
  • HGFL
  • MSP
  • NF15S2
  • D3F15S2h
  • D9H3F15S2
  • DNF15S2h
  • Hgfl
  • E2F2
  • HGF1/MSP
  • macrophage stimulating 1 (hepatocyte growth factor-like)
  • Macrophage stimulating 1 (hepatocyte growth factor-like)
  • MST1
  • Mst1
Epitope
AA 331-483
22
15
15
7
6
6
5
4
3
3
3
2
2
2
1
1
1
1
Reactivity
Human
93
23
19
3
2
2
2
2
1
Host
Mouse
75
25
Clonality (Clone)
Monoclonal ()
Conjugate
This MST1 antibody is un-conjugated
6
6
5
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
80
46
33
18
13
13
5
2
2
2
1
Options
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Immunogen Human MST1 aa. 331-483
Clone 7-MST1
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name MST1 (MST1 Antibody Abstract)
Background Ste20 is a S. cerevisiae Ser/Thr protein kinase that functions upstream of the MAP kinase module. Mammalian and yeast homologs of this kinase are divided into two classes based on their structure and regulation. Members of the first class (Ste20, Cla4, and p21-activated protein kinase [PAK]) contain a C-terminal kinase domain, an N-terminal regulatory domain and a small GTPase Rac1/Cdc42-binding domain. Members of the second class lack GTPase-binding sites, but are similar to the former class throughout the catalytic domain. The latter class includes GC kinase, HPK, KHS, KRS1 & 2, MST1, 2, & 3, and SOK-1. MST1 (Mammalian Sterile Twenty-like-1) is a ubiquitously expressed kinase that contains an N-terminal kinase domain and C-terminal dimerization and inhibitory domains. Apoptotic stimuli, such as anti-Fas, result in cleavage of the C-terminal regulatory domain by caspase-3 or a related caspase, and activation of MST1. Overexpression of MST1 induces caspase activity, apoptotic morphological changes, and the activation of the SAPK and p38 MAPK pathways. Thus, MST1 is thought to function as a component of a positive feedback loop that amplifies the apoptotic response.
Synonyms: Mammalian Sterile Twenty-like 1, Mammalian STE20-like kinase-1
Molecular Weight 56 kDa
Research Area Cancer, Innate Immunity, Signaling
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (ABIN968344) Western blot analysis of MST1 on a Jurkat cell lysate (Human T-cell leukemia, ATCC TI...
Immunofluorescence (IF) image for anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (ABIN968344) Immunofluorescence staining of human endothelial cells.
 image for anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (ABIN968344) anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (Image 3)
Western Blotting (WB) image for anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (ABIN968344) anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) (AA 331-483) antibody (Image 4)
Product cited in: Lian, Toker, Badwey: "Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 10, pp. 6349-57, 2001 (PubMed).

Creasy, Chernoff: "Cloning and characterization of a human protein kinase with homology to Ste20." in: The Journal of biological chemistry, Vol. 270, Issue 37, pp. 21695-700, 1995 (PubMed).

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