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Details for Product No. ABIN968345

Heme Oxygenase 2 (HO2) (AA 5-115) antibody

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Antigen
Synonyms T9J22.22, T9J22_22, heme oxygenase 2
Epitope
AA 5-115
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN968345
Quantity 50 µg
Price
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Immunogen Human HO-2
Clone DF5
Isotype IgG2b
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Heme Oxygenase 2
Background Heme Oxygenase (HO) mediates the degradation of heme into biliverdin, free iron, and carbon monoxide (CO). HO exists as two isozymes, designated HO-1 and HO-2. These two isoforms share about 40% amino acid similarity including several stretches of highly conserved sequences with matched predicted secondary structure. HO-1, the inducible form, is found primarily in spleen and liver Kupffer cells. However, HO-2 is constitutively expressed in abundance in brain, testis, and liver parenchymal cells. Although HO-1 has an established physiological role in heme catabolism, the HO-2 mechanism is unclear. However, the HO-2 heme- inding pocket is similar to that of HO-1 and heme degradation is thought to proceed by similar mechanisms. In the brain, HO-2 colocalizes with neuronal nitric oxide synthase (nNOS) within adventitial neurons and in autonomic ganglia. Like the neurotransmitter NO, CO produced by HO-2 stimulates guanylyl cyclase Also, HO-2 may function to limit acute and chronic inflammatory responses. Thus, HO-2 serves as a mediator of heme degradation and, in doing so, may generate molecules important for neurotransmission and possibly immunomodulation.
Molecular Weight 36 kDa
Comment

Related Products: ABIN968552, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Ishikawa, Takeuchi, Takahashi et al.: "Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2." in: The Journal of biological chemistry, Vol. 270, Issue 11, pp. 6345-50, 1995 (PubMed).

Willis, Moore, Frederick et al.: "Heme oxygenase: a novel target for the modulation of the inflammatory response." in: Nature medicine, Vol. 2, Issue 1, pp. 87-90, 1996 (PubMed).

Zakhary, Poss, Jaffrey et al.: "Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 26, pp. 14848-53, 1998 (PubMed).

Alternatives for antigen "Heme Oxygenase 2 (HO2)", type "Antibodies"
Hosts (1)
Reactivities (1)
Applications (1), (1), (1), (1)
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