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PPP1R10 antibody (AA 605-716)

PPP1R10 Reactivity: Human, Rat, Mouse WB, IF Host: Mouse Monoclonal 47-PNUTS unconjugated
Catalog No. ABIN968349
  • Target See all PPP1R10 Antibodies
    PPP1R10 (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 10 (PPP1R10))
    Binding Specificity
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 605-716
    Reactivity
    • 12
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 11
    • 1
    Mouse
    Clonality
    • 11
    • 1
    Monoclonal
    Conjugate
    • 12
    This PPP1R10 antibody is un-conjugated
    Application
    • 11
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Human, Mouse (Murine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat PNUTS aa. 605-716
    Clone
    47-PNUTS
    Isotype
    IgG1
    Top Product
    Discover our top product PPP1R10 Primary Antibody
  • Comment

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Allen, Kwon, Nairn, Greengard: "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit." in: The Journal of biological chemistry, Vol. 273, Issue 7, pp. 4089-95, (1998) (PubMed).

  • Target
    PPP1R10 (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 10 (PPP1R10))
    Alternative Name
    PNUTS (PPP1R10 Products)
    Synonyms
    CAT53 antibody, FB19 antibody, PNUTS antibody, PP1R10 antibody, R111 antibody, p99 antibody, Fb19 antibody, Pnuts antibody, 2610025H06Rik antibody, Cat53 antibody, D17Ertd808e antibody, CHUNP6885 antibody, fe15d12 antibody, fk54b08 antibody, ppp1r10l antibody, wu:fe15d12 antibody, wu:fk54b08 antibody, protein phosphatase 1 regulatory subunit 10 antibody, protein phosphatase 1, regulatory subunit 10 antibody, protein phosphatase 1 regulatory subunit 10 S homeolog antibody, PPP1R10 antibody, Ppp1r10 antibody, ppp1r10.S antibody, ppp1r10 antibody
    Background
    Many aspects of cellular physiology are influenced by the serine/threonine protein phosphatase1 (PP1). It is a highly conserved eukaryotic protein that reverses the action of protein kinases. PP1 is key to such processes as cell division, neuronal metabolism, and protein synthesis. It consists of a catalytic subunit, with a broad substrate specificity, whose action is directed by its association with a family of regulatory proteins including inhibitor-1, inhibitor-2, and NIPP-1. In response to extracellular stimuli, these proteins interact with PP1 and inhibit its catalytic activity. Other regulatory proteins are referred to as targeting subunits because they direct PP1 to specific subcellular locations and modulate its activity. In the cell nucleus, PP1 has been implicated in a variety of processes. Nuclear PP1 exists in high MW complexes with other proteins including NIPP-1. PNUTS (phosphatase 1 nuclear targeting subunit) is a ubiquitously expressed nuclear protein that forms a stable complex with PP1 and is thought to modulate its catalytic activity. Thus, PNUTS is a specific regulatory protein that directs the nuclear function of PP1.
    Molecular Weight
    110 kDa
    Pathways
    Protein targeting to Nucleus
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