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CD38 antibody (AA 171-292)

Details for Product anti-CD38 Antibody No. ABIN968373, Supplier: Log in to see
Antigen
  • Cd38-rs1
  • T10
  • CD38 antigen
  • CD38 molecule
  • Cd38
  • CD38
Epitope
AA 171-292
40
17
15
15
15
13
12
9
6
5
4
4
3
1
1
1
1
1
1
Reactivity
Human
502
208
22
3
1
1
1
Host
Mouse
414
154
107
11
3
Clonality (Clone)
Monoclonal ()
Conjugate
This CD38 antibody is un-conjugated
75
67
49
36
15
14
14
13
10
10
8
8
8
8
8
7
7
7
7
6
6
6
6
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
531
182
180
123
96
87
55
53
26
15
9
8
7
6
5
5
4
3
2
2
2
2
1
1
1
1
1
1
Options
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Immunogen Human CD38 aa. 171-292
Clone 22-CD38
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Background Lymphocyte trafficking is essential for efficient immune responses in that it allows antigen sensitive lymphocytes to encounter antigen and be recruited to sites of infection. Trafficking involves the passage of lymphocytes across the HEV, a process that is mediated by selectins. CD38 is a single-chain type II transmembrane glycoprotein that is expressed by a variety of immature and activated lymphocytes. It mediates a selectin-like binding to endothelial cells, thus functioning as an adhesion molecule. Human and mouse forms of the protein are highly similar and homologous to the Aplysia californica ADP-ribosyl-cyclase. CD38 catalyzes the synthesis of cyclic ADP-ribose (cADPR), a putative endogenous regulator of calcium release. This is thought to be key to CD38-mediated signal transduction. A possible ligand for CD38 is the Ig superfamily protein CD31. In addition, activation of CD38 with a monoclonal antibody induces leukemic cell proliferation. Thus, CD38 is a cell surface protein that is important for lymphocyte migration and may be involved in the propagation of leukemic cells in AML (acute myelogenous leukemia).
Molecular Weight 46 kDa
Research Area CD Antigens, Surface Receptors of Immune Cells
Comment

Related Products: ABIN967389, ABIN968584

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-CD38 antibody (AA 171-292) (ABIN968373) Western blot analysis of CD38 on EB1 lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:...
Immunofluorescence (IF) image for anti-CD38 antibody (AA 171-292) (ABIN968373) Immunofluorescence staining of Human Endothelial cells.
 image for anti-CD38 antibody (AA 171-292) (ABIN968373) anti-CD38 (AA 171-292) antibody (Image 3)
Western Blotting (WB) image for anti-CD38 antibody (AA 171-292) (ABIN968373) anti-CD38 (AA 171-292) antibody (Image 4)
Product cited in: Deaglio, Morra, Mallone, Ausiello, Prager, Garbarino, Dianzani, Stockinger, Malavasi: "Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 1, pp. 395-402, 1998 (PubMed).

Konopleva, Estrov, Zhao, Andreeff, Mehta: "Ligation of cell surface CD38 protein with agonistic monoclonal antibody induces a cell growth signal in myeloid leukemia cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 9, pp. 4702-8, 1998 (PubMed).

Background publications Jackson, Bell: "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 144, Issue 7, pp. 2811-5, 1990 (PubMed).