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Details for Product No. ABIN968393

Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (AA 479-580) antibody

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Synonyms LCCS3, PIP5K-GAMMA, PIP5Kgamma, PIPKIg_v4, AI115456, AI835305, Pip5kIgamma, MGC130766, PIP5K1C, pip5k1a, zgc:110576, si:dkey-29i9.1
»Alternatives AA 479-580
»Alternatives Mouse (Murine)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN968393
Quantity 50 µg
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Immunogen Mouse PIP5Kgamma
Clone 6G3
Isotype IgG1
Cross-Reactivity Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name PIP5K gamma
Background Phosphoinositide turnover is a well established mechanism of intracellular signal transduction. Sequential phosphorylation of phosphatidylinositol (PtdIns) results in PtdIns(4)P (PIP) and PtdIns(4,5)P2 (PIP2). Phospholipase C (PLC) hydrolyzes PIP2 to inositol (1,4,5)P3 (IP3) which stimulates release of intracellular Ca2+. PIP2 is generated by phosphorylation of PtdIns 5-kinases (PI5-K). These enzymes are divided into two types (I and II) based on their size and sensitivity to certain compounds. Three mammalian PI5-Ks, PI5-Kalpha, beta, and gamma of type I have been identified and a type II PIP5kalpha. Although the PI4-Ks are abundantly distributed throughout the cell, activity is found primarily in association with membranous structures. Members of this family contain a lipid kinase unique domain and a C-terminal catalytic domain.
Molecular Weight 87-90 kDa

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Ishihara, Shibasaki, Kizuki et al.: "Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family." in: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8741-8, 1998 (PubMed).

Tolias, Rameh, Ishihara et al.: "Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate." in: The Journal of biological chemistry, Vol. 273, Issue 29, pp. 18040-6, 1998 (PubMed).

Nishikawa, Toker, Wong et al.: "Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase." in: The Journal of biological chemistry, Vol. 273, Issue 36, pp. 23126-33, 1998 (PubMed).

Alternatives for antigen "Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C)", type "Antibodies"
Hosts (20), (3)
Reactivities (23)
Applications (23), (16), (6), (2), (1), (1)
Epitopes (5), (3), (2), (2), (2)