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PIP5K1C antibody (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma) (AA 479-580)

Details for Product anti-PIP5K1C Antibody No. ABIN968393, Supplier: Login to see New
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Antigen
Synonyms MGC130766, PIP5K1C, pip5k1a, zgc:110576, si:dkey-29i9.1, AI115456, AI835305, Pip5kIgamma, LCCS3, PIP5K-GAMMA, PIP5Kgamma, PIPKIg_v4
Alternatives
Epitope
AA 479-580
(10), (9), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus)
(39), (5), (4), (2)
Host
Mouse
(34), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
This PIP5K1C antibody is un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB)
(36), (27), (13), (4), (2), (2), (1)
Pubmed 3 references available
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Quantity 50 μg
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Immunogen Mouse PIP5Kgamma aa. 479-580
Clone 12-PIP5Kgamma
Isotype IgG1
Cross-Reactivity Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name PIP5K gamma (PIP5K1C Antibody Abstract)
Background Phosphoinositide turnover is a well established mechanism of intracellular signal transduction. Sequential phosphorylation of phosphatidylinositol (PtdIns) results in PtdIns(4)P (PIP) and PtdIns(4,5)P2 (PIP2). Phospholipase C (PLC) hydrolyzes PIP2 to inositol (1,4,5)P3 (IP3) which stimulates release of intracellular Ca2+. PIP2 is generated by phosphorylation of PtdIns 5-kinases (PI5-K). These enzymes are divided into two types (I and II) based on their size and sensitivity to certain compounds. Three mammalian PI5-Ks, PI5-Kalpha, beta, and gamma of type I have been identified and a type II PIP5kalpha. Although the PI4-Ks are abundantly distributed throughout the cell, activity is found primarily in association with membranous structures. Members of this family contain a lipid kinase unique domain and a C-terminal catalytic domain.
Molecular Weight 87-90 kDa
Pathways PI3K-Akt Signaling
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-PIP5K1C antibody (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma) (AA 479-580) (ABIN968393) Western blot analysis of PIP5Kgamma on a rat cerebrum lysate. Lane 1: 1:250, lane 2: ...
Immunofluorescence (IF) image for anti-PIP5K1C antibody (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma) (AA 479-580) (ABIN968393) Immunofluorescence staining of PC12 cells (Rat neuroblastoma, ATCC CRL-1721).
Image no. 3 for anti-PIP5K1C antibody (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma) (AA 479-580) (ABIN968393) anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (AA 479-580) antibody (Image 3)
Western Blotting (WB) image for anti-PIP5K1C antibody (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma) (AA 479-580) (ABIN968393) anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (AA 479-580) antibody (Image 4)
Product cited in: Nishikawa, Toker, Wong et al.: "Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase." in: The Journal of biological chemistry, Vol. 273, Issue 36, pp. 23126-33, 1998 (PubMed).

Tolias, Rameh, Ishihara et al.: "Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate." in: The Journal of biological chemistry, Vol. 273, Issue 29, pp. 18040-6, 1998 (PubMed).

Ishihara, Shibasaki, Kizuki et al.: "Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family." in: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8741-8, 1998 (PubMed).

Catalog No. ABIN968393
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