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Thrombospondin 2 antibody (AA 173-295)

THBS2 Reactivity: Mouse WB, IF Host: Mouse Monoclonal 4-Thrombospondin unconjugated
Catalog No. ABIN968394
  • Target See all Thrombospondin 2 (THBS2) Antibodies
    Thrombospondin 2 (THBS2)
    Binding Specificity
    • 15
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 173-295
    Reactivity
    • 35
    • 25
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 46
    • 4
    Mouse
    Clonality
    • 46
    • 4
    Monoclonal
    Conjugate
    • 19
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Thrombospondin 2 antibody is un-conjugated
    Application
    • 37
    • 16
    • 13
    • 13
    • 13
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Mouse (Murine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Thrombospondin-2 aa. 173-295
    Clone
    4-Thrombospondin
    Isotype
    IgG1
    Top Product
    Discover our top product THBS2 Primary Antibody
  • Comment

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Kyriakides, Zhu, Smith, Bain, Yang, Lin, Danielson, Iozzo, LaMarca, McKinney, Ginns, Bornstein: "Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis." in: The Journal of cell biology, Vol. 140, Issue 2, pp. 419-30, (1998) (PubMed).

    Kyriakides, Zhu, Yang, Bornstein: "The distribution of the matricellular protein thrombospondin 2 in tissues of embryonic and adult mice." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 46, Issue 9, pp. 1007-15, (1998) (PubMed).

    LaBell, Milewicz, Disteche, Byers: "Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans." in: Genomics, Vol. 12, Issue 3, pp. 421-9, (1992) (PubMed).

  • Target
    Thrombospondin 2 (THBS2)
    Alternative Name
    Thrombospondin-2 (THBS2 Products)
    Synonyms
    THBS1 antibody, tsp2 antibody, thbs2 antibody, TSP2 antibody, TMEM200A antibody, TSP-2 antibody, Thbs-2 antibody, thrombospondin 2 antibody, thrombospondin 2 L homeolog antibody, thrombospondin 2a antibody, THBS2 antibody, thbs2.L antibody, thbs2a antibody, Thbs2 antibody
    Background
    Cell adhesion interactions involve large extracellular glycoproteins such as fibronectin, laminins, and thrombospondins. The thrombospondins (TSPs), a small family of secreted glycoproteins, can be separated into two subfamilies based on structural similarity. TSP-1 and TSP-2 are homotrimers of monomeric 145 kDa chains, while TSP-3,4 and 5 are homopentamers of lower MW chains. TSP-1 and TSP-2 interact with several of the same cell surface receptors and have been termed matricellular proteins. However, the functional roles of TSP-1 and TSP-2 are poorly understood. Study of TSP-2 deficient mice has shed some light on the functional role of this protein. Although these mice appear normal, they in fact exhibit a wide variety of irregularities. These include abnormal collagen fiber development which results in fragile skin and highly flexible tendons and ligaments. They also exhibit increased cortical thickness in long bones and abnormal bleeding time. These results, together with the developmental expression pattern of TSP-2, suggest that it functions as a modulator of the cell surface properties of mesenchymal cells which, in turn, affects cell functions such as adhesion and migration. This antibody is routinely tested by western blot analysis.
    Synonyms: TSP-2
    Molecular Weight
    200 kDa
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