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Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) (AA 1-119) antibody

Details for Product No. ABIN968399, Supplier: Login to see
Antigen
  • cb929
  • cb1094
  • zgc:66248
  • wu:fj94c07
  • AGC1
  • ARALAR
  • Aralar1
  • RGD1561141
  • ARALAR1
  • 2610002D09Rik
  • AI839531
  • B230107K20Rik
  • BB129864
Epitope
AA 1-119
16
15
4
1
1
1
Reactivity
Human
41
18
15
1
1
1
Host
Mouse
41
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
24
21
21
10
6
Supplier
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Immunogen Human Aralar aa. 1-119
Clone 8-Aralar
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Aralar (Slc25a12 Antibody Abstract)
Background Mitochondria are the primary sites of ATP production within the cell. They contain two different membranes, the outer membrane and the inner membrane. The outer membrane contains porins which form pores in the membrane and render it highly permeable. The inner membrane is less permeable and contains a high protein-to-lipid ratio. This membrane contains a number of carrier proteins that mediate metabolite transport. These belong to a superfamily of related proteins that are found in S. cerevisiae, C. elegans, and several mammalian species. Aralar, a human member of this family, is expressed in the mitochondria within heart, skeletal muscle, and brain. Its C-terminal half resembles proteins of the mitochondrial solute carrier superfamily and its N-terminal portion contains four putative Ca2+-binding EF-hand domains. The presence of the EF-hands in Aralar make it a close relative of the large family of Ca2+-binding proteins that includes calmodulin and myosin light chain. Aralar is thought to function as a Ca2+-regulated mitochondrial anion carrier or as a Ca2+ and anion cotransporter since it is expressed primarily in tissues where cell function relies heavily on Ca2+- signaling.
Molecular Weight 70 kDa
Pathways
Comment

Related Products: ABIN968552, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) (AA 1-119) antibody (ABIN968399) Western blot analysis of Aralar on a SW-13 cell lysate (Human adrenal gland carcinoma...
Immunofluorescence (IF) image for anti-Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) (AA 1-119) antibody (ABIN968399) Immunofluorescence staining of A431 cells (Human epithelial carcinoma, ATCC CRL-1555).
 image for anti-Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) (AA 1-119) antibody (ABIN968399) anti-Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) (AA 1-119) antibody (Image 3)
Product cited in: del Arco, Satrústegui: "Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain." in: The Journal of biological chemistry, Vol. 273, Issue 36, pp. 23327-34, 1998 (PubMed).

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