Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) (AA 1-119) antibody

Details for Product No. ABIN968399
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Antigen
Synonyms cb929, cb1094, zgc:66248, wu:fj94c07, AGC1, ARALAR, Aralar1, RGD1561141, ARALAR1, 2610002D09Rik, AI839531, B230107K20Rik, BB129864
Epitope
AA 1-119
(9), (8), (3), (1), (1)
Reactivity
Human
(28), (15), (13), (13), (13), (1)
Host
Mouse
(28), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(16), (11), (10), (10), (5), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN968399
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Immunogen Human Aralar
Clone 8
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Aralar
Background Mitochondria are the primary sites of ATP production within the cell. They contain two different membranes, the outer membrane and the inner membrane. The outer membrane contains porins which form pores in the membrane and render it highly permeable. The inner membrane is less permeable and contains a high protein-to-lipid ratio. This membrane contains a number of carrier proteins that mediate metabolite transport. These belong to a superfamily of related proteins that are found in S. cerevisiae, C. elegans, and several mammalian species. Aralar, a human member of this family, is expressed in the mitochondria within heart, skeletal muscle, and brain. Its C-terminal half resembles proteins of the mitochondrial solute carrier superfamily and its N-terminal portion contains four putative Ca2+-binding EF-hand domains. The presence of the EF-hands in Aralar make it a close relative of the large family of Ca2+-binding proteins that includes calmodulin and myosin light chain. Aralar is thought to function as a Ca2+-regulated mitochondrial anion carrier or as a Ca2+ and anion cotransporter since it is expressed primarily in tissues where cell function relies heavily on Ca2+- signaling.
Molecular Weight 70 kDa
Comment

Related Products: ABIN968552, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) (AA 1-119) antibody Western blot analysis of Aralar on a SW-13 cell lysate (Human adrenal gland carcinoma, ATCC CCL-105). Lane 1: 1:2500, lane 2: 1:5000, lane 3: 1:10,000 dilution of the mouse anti-human Aralar antibody.
anti-Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) (AA 1-119) antibody (2) Immunofluorescence staining of A431 cells (Human epithelial carcinoma, ATCC CRL-1555).
anti-Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) (AA 1-119) antibody (3) anti-Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12) (AA 1-119) antibody (Image 3)
Product cited in: del Arco, Satrústegui: "Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain." in: The Journal of biological chemistry, Vol. 273, Issue 36, pp. 23327-34, 1998 (PubMed).

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