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TBP-Like 1 (TBPL1) (AA 316-427) antibody

Details for Product No. ABIN968416, Supplier: Log in to see
Antigen
  • 4732475G08
  • AW011832
  • AW491032
  • D18347
  • STD
  • TLF
  • TRF2
  • TRP
  • Tlp
  • MGC:8389
  • MGC:9620
  • STUD
  • TLP
  • tlf
  • tlp
  • trf
  • trf2
  • trp
  • zgc:92340
Epitope
AA 316-427
15
3
3
2
2
2
2
1
1
1
1
1
Reactivity
Dog (Canine), Human
60
29
25
8
4
3
1
1
1
1
Host
Mouse
38
16
6
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
5
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
42
28
13
11
8
4
2
2
1
1
Supplier
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Immunogen Human TRF2 aa. 316-427
Clone 36-TRF2
Isotype IgG1
Cross-Reactivity Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name TRF2 (TBPL1 Antibody Abstract)
Background Telomeres, the physical ends of eukaryotic chromosomes, consist of tracts of TTAGGG repeats that end in 3' single strand protrusions called G-strand overhangs. TRF2 (TTAGGG Repeat binding Factor-2) and TRF1 are two proteins that bind the TTAGGG repeats of mammalian telomeres. Both proteins are ubiquitously expressed and exhibit a similar overall structure with a C-terminal DNA binding motif related to the protooncogene Myb and an N-terminal putative dimerization domain. While TRF1 is a negative regulator of telomere length maintenance, TRF2 is involved in the protection of chromosome ends from end-to-end fusion. Telomere integrity is maintained through the formation of t loops which are made by the insertion of the G-strand overhang into the duplex repeat region. This structural alteration is mediated by TRF2 and is the primary mechanism for the sequestration and protection of telomeres from DNA damage responses. Cells that lack functional TRF2 undergo loss of G-strand overhangs, innapropriate DNA repair resulting in end-to-end chromosome fusion, cell cycle arrest and apoptosis. Thus, TRF2 is a unique and vital component for the maintenance of chromosome structure and function.
Synonyms: TTAGGG Repeat binding Factor-2
Molecular Weight 66 kDa
Research Area Cancer, Chromatin Binding Proteins, Transcription Factors, Cell Cycle, Signaling
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-TBP-Like 1 (TBPL1) (AA 316-427) antibody (ABIN968416) Western blot analysis of TRF2 on a Jurkat cell lysate (Human T-cell leukemia, ATCC TI...
 image for anti-TBP-Like 1 (TBPL1) (AA 316-427) antibody (ABIN968416) anti-TBP-Like 1 (TBPL1) (AA 316-427) antibody (Image 2)
Product cited in: Griffith, Comeau, Rosenfield et al.: "Mammalian telomeres end in a large duplex loop." in: Cell, Vol. 97, Issue 4, pp. 503-14, 1999 (PubMed).

van Steensel, Smogorzewska, de Lange: "TRF2 protects human telomeres from end-to-end fusions." in: Cell, Vol. 92, Issue 3, pp. 401-13, 1998 (PubMed).

Broccoli, Smogorzewska, Chong et al.: "Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2." in: Nature genetics, Vol. 17, Issue 2, pp. 231-5, 1997 (PubMed).