Intercellular Adhesion Molecule 1 (ICAM1) antibody

Antigen: Intercellular Adhesion Molecule 1 (ICAM1)

Synonyms: BB2, CD54, P3.58, Ly-47, Icam-1, MALA-2, MGC6195, ICAM-1, ICAM1, ICAM

Clonality: Monoclonal (15-Feb)

Host: Mouse

Reactivity: Human

Application: Immunohistochemistry (IHC)

Catalog no.: ABIN96842

Additional Information

Alternative name: CD54

Immunogen: Rheumatoid synovial cells and fibronectin adherent monocytes.

Format: Supernatant

Isotype: IgG1  (Matching secondary antibodies)

Clone: 15-Feb

Specificity: This antibody is specific to CD54 antigen of 90 kD. The CD54 antigen is expressed on monocytes and endothelial cells. The CD54 antigen is important in mediating immune and inflammatory response. The CD54 mediates the adhesion of T cells with antigen-presenting cells and is involved in T cell to T cell and T cell to B cell interactions.

Application Details

Application Notes: Titer/Working Dilution: This antibody may be diluted to a titer of 1:75-1:150 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Positive Control: Tonsil. Cellular localization: Cell membrane Other Applications: Immunoprecipitation, Western blotting (1:100-500).

Concentration: 100ug/ml approximately

Buffer: This antibody is supplied as purified immunoglobulin containing sodium azide as preservative.

Storage: Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.

Research Area: CD Antigens

Restrictions: For Research Use. CE-certified for In Vitro Diagnostics (IVD) Use in the European Union

Publications

Publications: Garioch, Mackie, Campbell et al.: "Keratinocyte expression of intercellular adhesion molecule 1 (ICAM-1) correlated with infiltration of lymphocyte function associated antigen 1 (LFA-1) positive cells in evolving allergic contact dermatitis reactions." in: Histopathology, Vol. 19, Issue 4, pp. 351-4, 1991 (PubMed).

Albelda, Buck: "Integrins and other cell adhesion molecules." in: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 4, Issue 11, pp. 2868-80, 1990 (PubMed).