Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

VTI1A antibody (AA 114-217)

VTI1A Reactivity: Human, Mouse, Rat, Dog WB, IF Host: Mouse Monoclonal 45-Vti1a unconjugated
Catalog No. ABIN968427
  • Target See all VTI1A Antibodies
    VTI1A (Vesicle Transport through Interaction with t-SNAREs 1A (VTI1A))
    Binding Specificity
    • 9
    • 8
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 114-217
    Reactivity
    • 43
    • 25
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog
    Host
    • 42
    • 2
    Mouse
    Clonality
    • 42
    • 2
    Monoclonal
    Conjugate
    • 17
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This VTI1A antibody is un-conjugated
    Application
    • 26
    • 20
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Rat (Rattus), Human, Dog (Canine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse Vti1a aa.114-217
    Clone
    45-Vti1a
    Isotype
    IgG1
    Top Product
    Discover our top product VTI1A Primary Antibody
  • Comment

    Related Products: ABIN967389, ABIN968545

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Chiu, Novikov, Mukherjee, Shields: "A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis." in: The Journal of cell biology, Vol. 159, Issue 4, pp. 637-48, (2002) (PubMed).

    Mallard, Tang, Galli, Tenza, Saint-Pol, Yue, Antony, Hong, Goud, Johannes: "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform." in: The Journal of cell biology, Vol. 156, Issue 4, pp. 653-64, (2002) (PubMed).

    Shorter, Beard, Seemann, Dirac-Svejstrup, Warren: "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115." in: The Journal of cell biology, Vol. 157, Issue 1, pp. 45-62, (2002) (PubMed).

    Advani, Bae, Bock, Chao, Doung, Prekeris, Yoo, Scheller: "Seven novel mammalian SNARE proteins localize to distinct membrane compartments." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10317-24, (1998) (PubMed).

    Xu, Wong, Tang, Subramaniam, Zhang, Hong: "A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway." in: The Journal of biological chemistry, Vol. 273, Issue 34, pp. 21783-9, (1998) (PubMed).

  • Target
    VTI1A (Vesicle Transport through Interaction with t-SNAREs 1A (VTI1A))
    Alternative Name
    Vti1a (VTI1A Products)
    Synonyms
    zgc:109895 antibody, mvti1 antibody, vti1-rp2 antibody, DDBDRAFT_0219803 antibody, DDBDRAFT_0231536 antibody, DDB_0219803 antibody, DDB_0231536 antibody, MMDS3 antibody, MVti1 antibody, VTI1RP2 antibody, Vti1-rp2 antibody, 1110014F16Rik antibody, 1110018K19Rik antibody, 4921537J05Rik antibody, MVti1a antibody, Vti1 antibody, vesicle transport through interaction with t-SNAREs 1A L homeolog antibody, vesicle transport through interaction with t-SNAREs 1A antibody, v-SNARE family protein antibody, vti1a.L antibody, vti1a antibody, VTI1A antibody, vti1A antibody, Vti1a antibody
    Background
    Eukaryotic protein trafficking involves the packaging of molecules into membranous vesicles that bud from a donor compartment, travel to a specific destination, fuse, and release their components into an acceptor compartment. Recognition between vesicle and acceptor membrane is mediated by the pairing of the integral membrane SNARE proteins. The stable interaction between vesicle proteins (v-SNAREs) and target proteins (t-SNAREs) juxtaposes the membranes and results in an activated docked state and/or membrane fusion. VTI1a and VTI1b are putative mammalian SNARE proteins identified by sequence comparison with yeast SNAREs. In line with their involvement in vesicle transport, these molecules are expressed in a wide range of mammalian tissues. Vti1a, a possible t-SNARE, contains a C-terminal hydrophobic domain and several regions that may form coiled-coil structures. It exists in distinct syntaxin 5- and syntaxin 6-containing SNARE complexes within the Golgi apparatus. Inhibition of Vti1a blocks transport of G proteins to the cell surface and results in their accumulation within the Golgi. Thus, Vti1a functions in protein transport within the secretory pathway.
    Molecular Weight
    29 kDa
You are here:
Support