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Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 36-156) antibody

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Synonyms sip1, sip1-delta, SIP1, SIP1-delta, 1700012N19Rik, Sip1, HSPC082, SIP-1, SMADIP1, ZFHX1B
AA 36-156
(10), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
(78), (46), (41), (3), (1)
(67), (12)
Clonality (Clone)
Monoclonal ()
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(60), (25), (19), (16), (13), (13), (9), (7), (2), (2), (2)
Pubmed 2 references available
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Quantity 50 μg
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Immunogen Human SIP1 aa. 36-156
Clone 4-SIP1
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name SIP1 (GEMIN2 Antibody Abstract)
Background Spinal muscular atrophy (SMA), a commonly fatal autosomal recessive disease, is caused by the degeneration of spinal anterior horn cells. It leads to symmetrical limb and trunk paralysis and muscular atrophy. SMA has been linked to the protein product of the Survival of Motor Neurons (SMN) gene. In greater than 98% of all SMA patients, SMN has been reported to be deleted or mutated. Although its function is unknown, the SMN protein is highly concentrated in novel nuclear structures, termed gems. SIP1 (SMN-interacting protein 1) forms a stable heteromeric complex with SMN and colocalizes with SMN in gems and in the cytoplasm. In SMA, the expression of both proteins is dramatically reduced in motor neurons. Additionally, SMN and SIP1 have been isolated from a 300 kDa protein complex that also contains spliceosomal snRNP proteins. In particular, the SMN-SIP1 complex associates with the spliceosomal snRNAs U1 and U5. Antibodies against the SMN-SIP1 complex interfere with the assembly and nuclear importation of spliceosomal complexes. Thus, it is thought that the SMN-SIP1 complex mediates the formation of spliceosomal snRNPs. However, the exact role of SIP1 in rRNA processing has yet to be determined. This antibody is routinely tested by western blot analysis.
Synonyms: SMN-Interacting Protein 1
Molecular Weight 32 kDa

Related Products: ABIN968586, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 36-156) antibody (ABIN968440) Western blot analysis of SIP1 on a K562 cell lysate. Lane 1: 1:250, lane 2: 1:500, la...
Immunofluorescence (IF) image for anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 36-156) antibody (ABIN968440) Immunofluorescence staining of human intestinal smooth muscle (HISM) cells.
Image no. 3 for anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 36-156) antibody (ABIN968440) anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 36-156) antibody (Image 3)
Western Blotting (WB) image for anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 36-156) antibody (ABIN968440) anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) (AA 36-156) antibody (Image 4)
Product cited in: Fischer, Liu, Dreyfuss: "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis." in: Cell, Vol. 90, Issue 6, pp. 1023-9, 1997 (PubMed).

Liu, Fischer, Wang et al.: "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins." in: Cell, Vol. 90, Issue 6, pp. 1013-21, 1997 (PubMed).

Catalog No. ABIN968440
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