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Details for Product No. ABIN968443

Neuropilin 2 (NRP2) (AA 610-721) antibody

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Antigen
Synonyms NP2, NPN2, PRO2714, VEGF165R2, 1110048P06Rik, Np-2, Np2, Npn-2, Npn2, neuropilin-2
Epitope
»Alternatives AA 610-721
Reactivity
»Alternatives Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN968443
Quantity 50 µg
Price
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Immunogen Rat Neuropilin-2
Clone 54
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Neuropilin-2
Background The precise navigation of axons to their targets in the developing nervous system is essential for establishment of neuronal connectivity. This is achieved through the recognition of attractant and repellent signals delivered to neurons by the netrins and semaphorins, which interact with receptors on axons and growth cones. The semaphorins are a large family of secreted and transmembrane glycoproteins that function as chemorepellents of developing neurons. Neuropilin-1 (NP-1) and neuropilin-2 (NP-2) (44% amino acid identity) are receptors for various members of the secreted semaphorin family. While NP-1 binds to class III semaphorins (Sema III, Sema E, and Sema IV), NP-2 is a high affinity receptor for Sema E and Sema IV, but not Sema III. Although they interact with distinct but overlapping subsets of semaphorins, NP-1 and NP-2 exhibit unique expression patterns during nervous system development. Moreover, NP-1 and NP-2 can form homooligomers which can, in turn, form heterooligomers. Thus, their interactions and differential patterns of expression implicate NP-1 and NP-2 in the coordination of axon guidance during neurodevelopment.
Synonyms: NP-2
Molecular Weight 104 kDa
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Kolodkin, Levengood, Rowe et al.: "Neuropilin is a semaphorin III receptor." in: Cell, Vol. 90, Issue 4, pp. 753-62, 1997 (PubMed).

Chen, Chédotal, He et al.: "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III." in: Neuron, Vol. 19, Issue 3, pp. 547-59, 1997 (PubMed).

Martin, Witte, Wong: "The synthesis and enzymatic incorporation of sialic acid derivatives for use as tools to study the structure, activity, and inhibition of glycoproteins and other glycoconjugates." in: Bioorganic & medicinal chemistry, Vol. 6, Issue 8, pp. 1283-92, 1999 (PubMed).

Giger, Urquhart, Gillespie et al.: "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity." in: Neuron, Vol. 21, Issue 5, pp. 1079-92, 1999 (PubMed).

Alternatives for antigen "Neuropilin 2 (NRP2)", type "Antibodies"
Hosts (37), (3), (2)
Reactivities (41), (24), (24), (18), (17), (17), (1), (1)
Applications (28), (15), (14), (10), (4), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (4), (2), (2), (2), (1), (1), (1), (1), (1)
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