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NRP2 antibody (Neuropilin 2) (AA 610-721)

Details for Product anti-NRP2 Antibody No. ABIN968443, Supplier: Login to see
Antigen
  • NP2
  • NPN2
  • PRO2714
  • VEGF165R2
  • 1110048P06Rik
  • Np-2
  • Np2
  • Npn-2
  • Npn2
  • neuropilin-2
Epitope
AA 610-721
19
15
7
5
5
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
Reactivity
Rat (Rattus)
63
21
15
2
1
1
Host
Mouse
60
6
3
Clonality (Clone)
Monoclonal ()
Conjugate
This NRP2 antibody is un-conjugated
3
3
3
2
2
2
1
Application
Immunofluorescence (IF), Western Blotting (WB)
52
37
10
2
2
2
1
1
Supplier
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Immunogen Rat Neuropilin-2 aa.610-721
Clone 54-Neuropilin
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Neuropilin-2 (NRP2 Antibody Abstract)
Background The precise navigation of axons to their targets in the developing nervous system is essential for establishment of neuronal connectivity. This is achieved through the recognition of attractant and repellent signals delivered to neurons by the netrins and semaphorins, which interact with receptors on axons and growth cones. The semaphorins are a large family of secreted and transmembrane glycoproteins that function as chemorepellents of developing neurons. Neuropilin-1 (NP-1) and neuropilin-2 (NP-2) (44% amino acid identity) are receptors for various members of the secreted semaphorin family. While NP-1 binds to class III semaphorins (Sema III, Sema E, and Sema IV), NP-2 is a high affinity receptor for Sema E and Sema IV, but not Sema III. Although they interact with distinct but overlapping subsets of semaphorins, NP-1 and NP-2 exhibit unique expression patterns during nervous system development. Moreover, NP-1 and NP-2 can form homooligomers which can, in turn, form heterooligomers. Thus, their interactions and differential patterns of expression implicate NP-1 and NP-2 in the coordination of axon guidance during neurodevelopment.
Synonyms: NP-2
Molecular Weight 104 kDa
Pathways
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-NRP2 antibody (Neuropilin 2) (AA 610-721) (ABIN968443) Western blot analysis of Neuropilin-2 on a rat cerebrum lysate. Lane 1: 1:250, lane 2...
 image for anti-NRP2 antibody (Neuropilin 2) (AA 610-721) (ABIN968443) anti-Neuropilin 2 (NRP2) (AA 610-721) antibody (Image 2)
Product cited in: Giger, Urquhart, Gillespie et al.: "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity." in: Neuron, Vol. 21, Issue 5, pp. 1079-92, 1999 (PubMed).

Martin, Witte, Wong: "The synthesis and enzymatic incorporation of sialic acid derivatives for use as tools to study the structure, activity, and inhibition of glycoproteins and other glycoconjugates." in: Bioorganic & medicinal chemistry, Vol. 6, Issue 8, pp. 1283-92, 1999 (PubMed).

Chen, Chédotal, He et al.: "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III." in: Neuron, Vol. 19, Issue 3, pp. 547-59, 1997 (PubMed).

Kolodkin, Levengood, Rowe et al.: "Neuropilin is a semaphorin III receptor." in: Cell, Vol. 90, Issue 4, pp. 753-62, 1997 (PubMed).