Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (AA 92-201) antibody

Details for Product No. ABIN968447
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Antigen
Synonyms clci, clns1b, icln, CLCI, CLNS1B, ICln, 2610036D06Rik, 2610100O04Rik, Clci, Clcni, ICLN, Icln, pICln, pIcIn
Epitope
AA 92-201
(10), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(33), (15), (12), (12), (12), (12)
Host
Mouse
(30), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(24), (10), (9), (5), (4), (3), (2), (2), (1)
Pubmed 3 references available
Quantity 50 µg
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Catalog No. ABIN968447
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Immunogen Human pICln
Clone TRAP-01
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name pICln
Background PICln (I = current, Cl = chloride, n = nucleotide-sensitive) was initially described as an integral component of a nucleotide-sensitive chloride channel. However, it lacks homology to known channel proteins and exhibits cytoplasmic and nuclear localization. Thus, pICln is thought to be a cytosolic regulator of a swelling-induced chloride channel, rather than a component of a channel itself. In support of this hypothesis, pICln interacts with several cytosolic proteins. It binds to several Sm proteins, which are common spliceosomal core proteins whose assembly is necessary for the biogenesis of small nuclear ribonucleoproteins (snRNPs). Sm protein association with pICln inhibits their assembly. pICln also interacts with the 72 kDa human homolog of Skb1, a yeast protein that binds a homolog of p21[Cdc42/Rac]-activated protein kinases. In addition, pICln interacts with, and is phosphorylated by, a constitutively active cytosolic protein kinase. Therefore, pICln is thought to be a component of signaling pathways that function in transcriptional or translational regulation, cytoskeletal reorganization, or a number of other biological processes.
Molecular Weight 37/42 kDa
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (AA 92-201) antibody Western blot analysis of pICIn on A431 lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of pICIn.
anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (AA 92-201) antibody (2) HCT-8
anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (AA 92-201) antibody (3) anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (AA 92-201) antibody (Image 3)
Product cited in: Krapivinsky, Pu, Wickman et al.: "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 10811-4, 1998 (PubMed).

Sanchez-Olea, Emma, Coghlan et al.: "Characterization of pICln phosphorylation state and a pICln-associated protein kinase." in: Biochimica et biophysica acta, Vol. 1381, Issue 1, pp. 49-60, 1998 (PubMed).

Pu, Krapivinsky, Krapivinsky et al.: "pICln inhibits snRNP biogenesis by binding core spliceosomal proteins." in: Molecular and cellular biology, Vol. 19, Issue 6, pp. 4113-20, 1999 (PubMed).

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