STRAP antibody (AA 42-154)

Catalog No. ABIN968485

Product Details anti-STRAP Antibody

Target: STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

Binding Specificity: AA 42-154

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This STRAP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Rat (Rattus), Human

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse STRAP aa. 42-154

Clone: 22-STRAP

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN968545, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-STRAP antibody (ABIN968485)

Datta, Chytil, Gorska, Moses: "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling." in: The Journal of biological chemistry, Vol. 273, Issue 52, pp. 34671-4, (1999) (PubMed).

Target Details for STRAP

Target: STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

Alternative Name: STRAP (STRAP Products)

Synonyms: MAWD antibody, PT-WD antibody, UNRIP antibody, zgc:56677 antibody, zgc:77604 antibody, mawd antibody, pt-wd antibody, unrip antibody, AW557906 antibody, C78091 antibody, C79202 antibody, Unrip antibody, serine/threonine kinase receptor associated protein antibody, tetratricopeptide repeat domain 5 antibody, serine/threonine kinase receptor associated protein L homeolog antibody, serine/threonine kinase receptor associated protein S homeolog antibody, STRAP antibody, TTC5 antibody, strap antibody, strap.L antibody, strap.S antibody, Strap antibody

Background: The transforming growth factor beta (TGF-beta) family of cytokines plays diverse and important roles in growth, development, and differentiation. Three high affinity TGF-beta receptor types have been characterized. Both type I and type II receptors are type I transmembrane proteins which contain a Ser/Thr-kinase in their cytosolic domains. Type III receptor, also known as betaglycan, has no cytosolic signaling motif and functions in the presentation of TGF-beta to the type I and type II receptors. The cytosolic domain kinase of the type I receptor is thought to be transphosphorylated by the corresponding kinase of the type II receptor, leading to activation of downstream substrates. Ser/Thr receptor associated protein (STRAP) contains six WD domains, which are characteristic of signal transduction proteins. STRAP can associate with both TGF-betaI and TGF-betaII receptors and overexpression of STRAP leads to inhibition of TGF-beta-dependent transcriptional activation. STRAP is expressed ubiquitously in species ranging from yeast to human. Thus, STRAP may be an important element of TGF-beta signal transduction pathways in a variety of tissues and species.

Molecular Weight: 39 kDa