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Details for Product No. ABIN968487

Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1) (AA 110-230) antibody

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Antigen
Synonyms mu2, AP50, CLAPM1, Ap50, Clapm1, ap2m1-a, cb34, Ap2m1, dpy-23, sb:cb34, zgc:55711, zgc:85653, wu:fa97a10, ap2m1, zgc:56643, AP2M1
Epitope
»Alternatives AA 110-230
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 2 references available
Catalog no. ABIN968487
Quantity 50 µg
Price
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Immunogen Mouse AP50/µ2
Clone TFR-01
Isotype IgG1
Cross-Reactivity Rat (Rattus), Human
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name AP50
Background Sorting of integral membrane proteins is mediated vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (gamma, alpha, delta, epsilon, and beta1, beta2, beta3, beta4 respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, µ4 respectively) and one small chain ( sigma1, sigma2, sigma3, sigma4 respectively). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2, µ2 (AP50) interacts with integral membrane proteins via binding to tyrosine-based signals with the canonical motif YXXPhi. In addition, AP50/µ2 is required for both the assembly and the proton transport activity of vacuolar (H+)-ATPases in clathrin coated vesicles. Thus, AP50/µ2 may be involved in targeting integral membrane proteins that are sorted based on tyrosine-based signals and involved in assembly of functional ion channels associated with clathrin coated vesicles.
Molecular Weight 50 kDa
Comment

Related Products: ABIN968545, ABIN967389, ABIN968533

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Ohno, Stewart, Fournier et al.: "Interaction of tyrosine-based sorting signals with clathrin-associated proteins." in: Science (New York, N.Y.), Vol. 269, Issue 5232, pp. 1872-5, 1995 (PubMed).

Vecchi, Polo, Poupon et al.: "Nucleocytoplasmic shuttling of endocytic proteins." in: The Journal of cell biology, Vol. 153, Issue 7, pp. 1511-7, 2001 (PubMed).

Alternatives for antigen "Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1)", type "Antibodies"
Hosts (52), (12), (9)
Reactivities (69), (48), (47), (13), (12), (3), (2)
Applications (55), (31), (20), (14), (14), (9), (5)
Conjugates (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (10), (4), (4), (3), (2), (1), (1), (1)
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