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STX8 antibody (Syntaxin 8) (AA 57-164)

Details for Product anti-STX8 Antibody No. ABIN968490, Supplier: Log in to see
Antigen
  • CG4109
  • Dm Syx8
  • DmSyx8
  • Dmel\\CG4109
  • SYX8
  • Syx
  • zgc:64079
  • syntaxin-8
  • STX8
  • GB11192
  • MGC116467
  • DDBDRAFT_0217663
  • DDBDRAFT_0231533
  • DDB_0217663
  • DDB_0231533
  • CARB
  • 0610007H08Rik
  • 1110002H11Rik
  • 4930571E13Rik
Epitope
AA 57-164
18
16
7
5
4
2
2
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
29
24
8
1
1
Host
Mouse
35
7
1
Clonality (Clone)
Monoclonal ()
Conjugate
This STX8 antibody is un-conjugated
2
2
2
2
2
2
Application
Immunofluorescence (IF), Western Blotting (WB)
38
21
5
1
1
1
1
Supplier
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Immunogen Mouse Syntaxin 8 aa. 57-164
Clone 48-Syntaxin 8
Isotype IgG2a
Cross-Reactivity Human, Dog (Canine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Syntaxin 8 (STX8 Antibody Abstract)
Background Eukaryotic protein trafficking involves the packaging of molecules into membranous vesicles that bud from a donor compartment, travel to a specific destination, fuse, and release their components into an acceptor compartment. Recognition between vesicle and acceptor membrane is mediated by the pairing of the integral membrane SNARE proteins. The stable interaction between vesicle proteins (v-SNAREs) and target proteins (t-SNAREs) juxtaposes the membranes and results in an activated docking state and/or membrane fusion. The syntaxin protein family contains a number of members that serve as functional t-SNAREs. One member of this family, syntaxin 8, has two coiled-coil domains, one in the N-terminus and one toward the C-terminus. The C-terminal domain is homologous to a similar domain in syntaxin 6 and is predicted to interact in the formation of SNARE complexes, while a hydrophobic domain in the C-terminus may be involved in membrane anchoring. Syntaxin-8 is ubiquitously expressed, but is present at high levels in the heart and localizes specifically to the ER. Thus, syntaxin-8 is a t-SNARE that is thought to be involved in the early secretory pathway of many different cell types.
Molecular Weight 27 kDa
Research Area Signaling, Organelles, Chromatin and Nuclear Signaling, Cytoskeleton, Microfilaments
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-STX8 antibody (Syntaxin 8) (AA 57-164) (ABIN968490) Western blot analysis of Syntaxin 8 on human cell endothelial lysate. Lane 1: 1:1000,...
Immunofluorescence (IF) image for anti-STX8 antibody (Syntaxin 8) (AA 57-164) (ABIN968490) Immunofluorescent staining of WI38 cells.
 image for anti-STX8 antibody (Syntaxin 8) (AA 57-164) (ABIN968490) anti-Syntaxin 8 (STX8) (AA 57-164) antibody (Image 3)
Western Blotting (WB) image for anti-STX8 antibody (Syntaxin 8) (AA 57-164) (ABIN968490) anti-Syntaxin 8 (STX8) (AA 57-164) antibody (Image 4)
Product cited in: Thoreau, Bergès, Callebaut et al.: "Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8)." in: Biochemical and biophysical research communications, Vol. 257, Issue 2, pp. 577-83, 1999 (PubMed).

Steegmaier, Yang, Yoo et al.: "Three novel proteins of the syntaxin/SNAP-25 family." in: The Journal of biological chemistry, Vol. 273, Issue 51, pp. 34171-9, 1999 (PubMed).