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Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 1366-1473) antibody

Details for Product No. ABIN968510
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Antigen
Synonyms N-CoR, SMRT, SMRTe, CTG26, N-CoR2, SMAP270, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1
Epitope
AA 1366-1473
(16), (5), (3), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(48), (16), (16), (14), (12), (12)
Host
Mouse
(34), (14), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(24), (14), (10), (10), (8), (6), (6), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 50 µg
Options
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Catalog No. ABIN968510
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Immunogen Human SMRT
Clone DF5
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name SMRT
Background Steroid nuclear hormone receptors regulate physiological homeostasis through repression and activation of gene transcription. In the absence of hormone, DNA-bound steroid receptors recruit corepressor, such as silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptorcorepressor (N-CoR), which bind to the free ligand binding domain of the thyroid hormone receptor, retinoic acid receptor, and other nuclear receptors. SMRT and N-CoR form a large protein complex with histone deacetylase I (HDAC1) and Sin3A, which deacetylates histones to alter chromatin structure in a manner that inhibits transcription. In addition, SMRT and N-CoR proteins interact with the transcription factor CBF/RBP-Jk to regulate Notch signaling pathways. SMRT contains four domains related to repressor activity (RD1, RD2, SRD1, and SRD2), two receptor interaction domains (RID1 and RID2), and a SANT region that is found in yeast chromatin remodeling factor SWI3. The ubiquitous expression pattern and corepressor activity of SMRT indicates that this protein is important for hormonal control of gene transcription in many tissues.
Molecular Weight 340 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 1366-1473) antibody Western blot analysis of SMRT on Jurkat cell lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-SMRT antibody.
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 1366-1473) antibody (2) Immunofluorescent staining of Wi38 cells with anti-SMRT antibody.
Product cited in: Chen, Evans: "A transcriptional co-repressor that interacts with nuclear hormone receptors." in: Nature, Vol. 377, Issue 6548, pp. 454-7, 1995 (PubMed).

Nagy, Kao, Chakravarti et al.: "Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase." in: Cell, Vol. 89, Issue 3, pp. 373-80, 1997 (PubMed).

Wagner, Norris, Knotts et al.: "The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor." in: Molecular and cellular biology, Vol. 18, Issue 3, pp. 1369-78, 1998 (PubMed).

Ordentlich, Downes, Xie et al.: "Unique forms of human and mouse nuclear receptor corepressor SMRT." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 6, pp. 2639-44, 1999 (PubMed).

Validation Images
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