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NCOR2 antibody (Nuclear Receptor Co-Repressor 2) (AA 1366-1473)

Details for Product anti-NCOR2 Antibody No. ABIN968511, Supplier: Login to see New
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Synonyms N-CoR, SMRT, SMRTe, CTG26, N-CoR2, SMAP270, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1
AA 1366-1473
(12), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(56), (18), (18), (2)
(40), (15), (1)
Clonality (Clone)
Monoclonal ()
This NCOR2 antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(32), (14), (13), (11), (10), (6), (5), (4), (3), (2), (2), (1)
Pubmed 4 references available
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Quantity 150 μg
Shipping to United States ( )
Immunogen Human SMRT aa. 1366-1473
Clone 44-SMRT
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name SMRT (NCOR2 Antibody Abstract)
Background Steroid nuclear hormone receptors regulate physiological homeostasis through repression and activation of gene transcription. In the absence of hormone, DNA-bound steroid receptors recruit corepressor, such as silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptorcorepressor (N-CoR), which bind to the free ligand binding domain of the thyroid hormone receptor, retinoic acid receptor, and other nuclear receptors. SMRT and N-CoR form a large protein complex with histone deacetylase I (HDAC1) and Sin3A, which deacetylates histones to alter chromatin structure in a manner that inhibits transcription. In addition, SMRT and N-CoR proteins interact with the transcription factor CBF/RBP-Jk to regulate Notch signaling pathways. SMRT contains four domains related to repressor activity (RD1, RD2, SRD1, and SRD2), two receptor interaction domains (RID1 and RID2), and a SANT region that is found in yeast chromatin remodeling factor SWI3. The ubiquitous expression pattern and corepressor activity of SMRT indicates that this protein is important for hormonal control of gene transcription in many tissues.
Molecular Weight 340 kDa
Pathways Notch Signaling

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-NCOR2 antibody (Nuclear Receptor Co-Repressor 2) (AA 1366-1473) (ABIN968511) Western blot analysis of SMRT on Jurkat cell lysate. Lane 1: 1:250, lane 2: 1:500, la...
Immunofluorescence (IF) image for anti-NCOR2 antibody (Nuclear Receptor Co-Repressor 2) (AA 1366-1473) (ABIN968511) Immunofluorescent staining of Wi38 cells with anti-SMRT antibody.
 image for anti-NCOR2 antibody (Nuclear Receptor Co-Repressor 2) (AA 1366-1473) (ABIN968511) anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 1366-1473) antibody (Image 3)
Western Blotting (WB) image for anti-NCOR2 antibody (Nuclear Receptor Co-Repressor 2) (AA 1366-1473) (ABIN968511) anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 1366-1473) antibody (Image 4)
Product cited in: Ordentlich, Downes, Xie et al.: "Unique forms of human and mouse nuclear receptor corepressor SMRT." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 6, pp. 2639-44, 1999 (PubMed).

Wagner, Norris, Knotts et al.: "The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor." in: Molecular and cellular biology, Vol. 18, Issue 3, pp. 1369-78, 1998 (PubMed).

Nagy, Kao, Chakravarti et al.: "Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase." in: Cell, Vol. 89, Issue 3, pp. 373-80, 1997 (PubMed).

Chen, Evans: "A transcriptional co-repressor that interacts with nuclear hormone receptors." in: Nature, Vol. 377, Issue 6548, pp. 454-7, 1995 (PubMed).

Catalog No. ABIN968511
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