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phosphodiesterase 5A, CGMP-Specific (PDE5A) (AA 2-108) antibody

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Synonyms PDE5A, pde5a, cgb-pde, cn5a, pde5, pde5a1, CGB-PDE, CN5A, PDE5, Cgbpde, Cn5n, Pde5, Pde5a1, PDE5A2
AA 2-108
(12), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Rat (Rattus)
(31), (16), (11), (5), (4), (3), (2), (1), (1)
(21), (7), (5)
Clonality (Clone)
Monoclonal ()
(3), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(28), (18), (13), (11), (10), (9), (5), (2), (2), (1), (1)
Pubmed 3 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Rat cGB-PDE aa. 2-108
Clone 54-cGB
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name cGB-PDE (PDE5A Antibody Abstract)
Background CGMP is involved in nitric oxide signaling, as well as cell signaling associated with natriuretic peptides and guanylins. Intracellular targets for cGMP include cGMP-dependent protein kinase, cyclic nucleotide-gate ion channels, and cGMP-Binding PhosphoDiesterases (cGB-PDE). Tissue levels of cGMP are determined by guanylyl cyclases that catalyze the formation of cGMP and cyclic nucleotide PDEs that catalyze the breakdown of cGMP. In the PDE superfamily PDE2, PDE5, PDE6, and PDE10 have dimeric structures that contain highly cGMP-specific allosteric cGMP binding sites in addition to a phosphodiesterase catalytic site. PDE5 is highly expressed in aorta and lung, but is also expressed in intestine, kidney, adrenal gland, cerebellum, and cerebrum. In the cerebellum, PDE5 is expressed in the Purkinje cell layer during neonatal development. PDE5 is also abundant in vascular smooth muscle cells where it is involved in regulating cGMP levels and vascular smooth muscle tonicity. Thus, PDE5 is important for regulating cGMP levels in both neuronal and non-neuronal tissues that utilize cGMP signaling pathways for the regulation of cell function.
Synonyms: PDE5, cGMP-Binding PhosphoDiesterases
Molecular Weight 85-95 kDa

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-phosphodiesterase 5A, CGMP-Specific (PDE5A) (AA 2-108) antibody (ABIN968563) Western blot analysis of cGB-PDE on a rat lung lysate. Lane 1: 1:500, lane 2: 1:1000,...
Product cited in: Corbin, Francis: "Cyclic GMP phosphodiesterase-5: target of sildenafil." in: The Journal of biological chemistry, Vol. 274, Issue 20, pp. 13729-32, 1999 (PubMed).

Kotera, Fujishige, Akatsuka et al.: "Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase." in: The Journal of biological chemistry, Vol. 273, Issue 41, pp. 26982-90, 1998 (PubMed).

Kotera, Yanaka, Fujishige et al.: "Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development." in: European journal of biochemistry / FEBS, Vol. 249, Issue 2, pp. 434-42, 1997 (PubMed).

Catalog No. ABIN968563
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