CTNND2 antibody (AA 85-194)

Catalog No. ABIN968579

Product Details anti-CTNND2 Antibody

Target: CTNND2 (Catenin (Cadherin-Associated Protein), delta 2 (Neural Plakophilin-Related Arm-Repeat Protein (CTNND2))

Binding Specificity: AA 85-194

Reactivity: Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTNND2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Rat (Rattus)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse delta-Catenin aa. 85-194

Clone: 30-delta

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN968545, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-CTNND2 antibody (ABIN968579)

Akins, Greer: "Axon behavior in the olfactory nerve reflects the involvement of catenin-cadherin mediated adhesion." in: The Journal of comparative neurology, Vol. 499, Issue 6, pp. 979-89, (2007) (PubMed).

Izawa, Nishizawa, Ohtakara, Inagaki: "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5345-50, (2002) (PubMed).

Laura, Witt, Held, Gerstner, Deshayes, Koehler, Kosik, Sidhu, Lasky: "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF." in: The Journal of biological chemistry, Vol. 277, Issue 15, pp. 12906-14, (2002) (PubMed).

Ho, Zhou, Medina, Goto, Jacobson, Bhide, Kosik: "delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development." in: The Journal of comparative neurology, Vol. 420, Issue 2, pp. 261-76, (2000) (PubMed).

Lu, Paredes, Medina, Zhou, Cavallo, Peifer, Orecchio, Kosik: "delta-catenin, an adhesive junction-associated protein which promotes cell scattering." in: The Journal of cell biology, Vol. 144, Issue 3, pp. 519-32, (1999) (PubMed).

Target Details for CTNND2

Target: CTNND2 (Catenin (Cadherin-Associated Protein), delta 2 (Neural Plakophilin-Related Arm-Repeat Protein (CTNND2))

Alternative Name: delta-Catenin (CTNND2 Products)

Synonyms: CTNND2 antibody, Catnd2 antibody, Nprap antibody, neurojugin antibody, GT24 antibody, NPRAP antibody, ctnnd2 antibody, si:dkey-40c17.4 antibody, catenin delta 2 antibody, delta-catenin antibody, catenin delta-2 antibody, catenin (cadherin associated protein), delta 2 antibody, catenin (cadherin-associated protein), delta 2b antibody, CTNND2 antibody, BACOIKO001_27 antibody, LOC100070792 antibody, Ctnnd2 antibody, ctnnd2b antibody

Background: The catenins (alpha, beta, gamma, delta, p120[ctn]) are cytoplasmic proteins that are related to the Drosophila Armadillo protein. Catenins may have dual roles since they are components of cell-cell adherens junctions and can translocate to the nucleus after stimulation of the Wingless (Wnt-1 homolog) signaling pathway. alpha-Catenin has two subtypes: alphaE-Catenin, which is expressed ubiquitously, and alphaN-Catenin, which is expressed in the nervous system. beta-Catenin binds to the cytoplasmic tail of E-Cadherin at adherens junctions and has been implicated in Wnt-1 signaling. gamma-Catenin is associated with desmoglein in desmosomes and is closely related to beta-Catenin. p120[ctn] is related to both beta- and gamma-catenin and is a substrate of tyrosine kinases localized at adherens junctions. delta-catenin was identified by its ability to bind the Alzheimer's disease-related protein, presenilin-1. It is most closely related to p120[ctn] and the desmosomal protein, p0071. It contains 10 Armadillo (Arm) repeats, as compared to the 13 Arm repeats found in beta-Catenin. delta-Catenin is expressed at high levels in the developing nervous system, where it may be involved in neuronal progenitor cell migration and dendrite development.

Molecular Weight: 160 kDa