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Details for Product No. ABIN968582

Protein Arginine Methyltransferase 5 (PRMT5) (AA 423-624) antibody

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Antigen
Synonyms Jbp1, Skb1, skb1, wu:fb95f10, zgc:110669, si:zc14a17.2, SKB1, hsl7, JBP1, IBP72, SKB1Hs, HRMT1L5, DDBDRAFT_0187422, DDBDRAFT_0235403, DDB_0187422, DDB_0235403, NV18830, jbp1, ibp72, skb1hs, hrmt1l5
Epitope
»Alternatives AA 423-624
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN968582
Quantity 150 µg
Price
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Immunogen Human Skb1Hs
Clone TRAP-01
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name JBP1
Background P21[Cdc42/Rac]-activated kinases (PAKs) bind and are activated by the small GTPases, Cdc42 and Rac. In yeast, the interaction of the PAK, Shk1, with Skb1 (Shk1 kinase binding protein 1) is important in the regulation of cell morphology and mitosis. Skb1Hs, the human homolog of Skb1, restores growth rates in yeast cells deficient for Skb1. Skb1Hs has also been identified as a 72 kDa pICln-binding protein (IBP72). pICln is thought to be a cytosolic regulator of a swelling-induced chloride channel and interactions with Skb1Hs suggest a link with PAKs, which are involved in cytoskeletal rearrangement. An additional line of study has identified Skb1Hs as a Jak binding protein (JBP1) via its interactions with Jak1-3 and Tyk2. This study also identified Skb1Hs as a methyltransferase that interacts with multiple proteins which possibly serve as physiological targets. Skb1Hs is expressed in a wide range of tissues and is thought to form homodimeric or multimeric complexes. Thus, Skb1Hs (IBP72, JBP1) is a multifunctional protein that may participate in such diverse processes as transcriptional and translational regulation, cytoskeletal rearrangement, and any of a number of signaling pathways.
Molecular Weight 72 kDa
Comment

Related Products: ABIN968552

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Krapivinsky, Pu, Wickman et al.: "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 10811-4, 1998 (PubMed).

Gilbreth, Yang, Bartholomeusz et al.: "Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14781-6, 1999 (PubMed).

Pollack, Kotenko, He et al.: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, 1999 (PubMed).

Alternatives for antigen "Protein Arginine Methyltransferase 5 (PRMT5)", type "Antibodies"
Hosts (55), (5), (4)
Reactivities (59), (25), (24), (16), (15), (14), (3), (3), (1), (1)
Applications (53), (21), (14), (13), (10), (7), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1)
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