COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (AA 234-334) antibody

Details for Product No. ABIN968614
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Antigen
Synonyms
BcDNA.LD14392, BcDNA:LD14392, CG14884, CH5, CSN-5, Csn5, DCH5, Dch5, Dmel\\CG14884, JAB1, JAB1/CSN5, Jab1, JadBp, csn5, dch5, jab1/csn5, l(3)89Cf, l(3)L4032, l(3)M203, quo, COPS5, MGC76063, AI303502,  ... show more
BcDNA.LD14392, BcDNA:LD14392, CG14884, CH5, CSN-5, Csn5, DCH5, Dch5, Dmel\\CG14884, JAB1, JAB1/CSN5, Jab1, JadBp, csn5, dch5, jab1/csn5, l(3)89Cf, l(3)L4032, l(3)M203, quo, COPS5, MGC76063, AI303502, CSN5, Mov34, Sgn5, zgc:73130, MOV-34, SGN5 show less
Epitope
AA 234-334
(16), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(68), (54), (30), (13), (13), (12), (1), (1), (1), (1), (1)
Host
Mouse
(59), (18), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(59), (32), (21), (16), (16), (13), (10), (6)
Pubmed 6 references available
Quantity 50 μg
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Catalog No. ABIN968614
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Immunogen Human JAB1
Clone BF12
Isotype IgG1
Cross-Reactivity Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name JAB1
Background JAB1 (Jun activation domain-binding protein-1) was isolated in a yeast two- hybrid screen using the c-Jun N-terminal activation domain. Binding of JAB1 to Jun potentiates activator protein transcription factor (AP-1) target gene transcription. JAB1 interacts with c-Jun and JunD, but not with JunB or v-Jun. It also interacts with other transcriptional regulatory complexes, such as the activator of stromelysin 1 gene transcription complex (RNF4/SPBP) and the steroid receptor coactivator-1 complex. Additionally, JAB1 is the CSN5 subunit of the COP9 signalosome, which contains multiple proteins with homologies to proteins present in the 19S subunit of the proteosome. Interestingly, JAB1 has been implicated in the instigation of p27kip1 and rat lutropin/choriogonadotropin receptor degradation. JAB1 has also been found to be involved in integrin signaling cascades, because it colocalizes with the integrin LFA-1 receptor and is translocated to the nucleus, where it enhances transactivation of the AP-1- dependent promoter following integrin stimulation. Thus, JAB1 is a multifunctional protein that regulates both gene transcription and protein degradation.
Molecular Weight 38 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (AA 234-334) antibody Immunofluorescent staining of A431 cells.
anti-COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5) (AA 234-334) antibody (2) Western blot analysis of JAB1 on Jurkat cell lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-JAB1 antibody.
Product cited in: Claret, Hibi, Dhut et al.: "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors." in: Nature, Vol. 383, Issue 6599, pp. 453-7, 1996 (PubMed).

Tomoda, Kubota, Kato: "Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1." in: Nature, Vol. 398, Issue 6723, pp. 160-5, 1999 (PubMed).

Chauchereau, Georgiakaki, Perrin-Wolff et al.: "JAB1 interacts with both the progesterone receptor and SRC-1." in: The Journal of biological chemistry, Vol. 275, Issue 12, pp. 8540-8, 2000 (PubMed).

Li, Liu, Ascoli: "p38JAB1 binds to the intracellular precursor of the lutropin/choriogonadotropin receptor and promotes its degradation." in: The Journal of biological chemistry, Vol. 275, Issue 18, pp. 13386-93, 2000 (PubMed).

Ishida, Hara, Kamura et al.: "Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export." in: The Journal of biological chemistry, Vol. 277, Issue 17, pp. 14355-8, 2002 (PubMed).

Kamura, Hara, Matsumoto et al.: "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase." in: Nature cell biology, Vol. 6, Issue 12, pp. 1229-35, 2004 (PubMed).

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