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Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (AA 120-241) antibody

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Synonyms ufd1, Ufd1, UFD1, wu:fc55f04, zgc:92341
AA 120-241
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(53), (23), (21)
(35), (17)
Clonality (Clone)
Monoclonal ()
(2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(37), (11), (11), (11), (6), (6), (5), (4), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 50 μg
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Immunogen Mouse Ufd1L aa. 120-241
Clone 19-Ufd1L
Isotype IgG1
Cross-Reactivity Human, Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name Ufd1L (UFD1L Antibody Abstract)
Background Microdeletions of the chromosomal region 22q11.2 are associated with defects in cardiac and craniofacial development that are referred to as the CATCH 22 phenotype and include DiGeorge syndrome, the velo-cardio-facial syndrome, and the Opitz GBBB syndrome. Deleted in CATCH 22 patients, UFD1L encodes the human homolog of the yeast ubiquitin fusion degradation 1 protein (UFD1p), an essential component of the ubiquitin-dependent proteolytic pathway. The murine homolog (Ufd1l) is expressed in the eyes and in the inner ear primordia during embryogenesis. In rat liver cytosol, Ufd1l binds to the nuclear transport protein Npl4 and this binary complex competes with p47 for binding to p97, which inhibits Golgi membrane fusion. The tertiary complex Ufd1l/Npl4/p97 may also be involved in mitotic ubiquitin-dependent processes. Both Ufd1l and Npl4 are found in the nucleus, while p97 is found in the cytoplasm and nucleus. In humans, Ufd1L is primarily expressed in adult heart, placenta, skeletal muscle, and pancreas, and fetal liver and kidney. Thus, Ufd1L is thought to be involved in cell functions that are critical for normal cell development in the cardiac and craniofacial regions.
Molecular Weight 40 kDa

Related Products: ABIN968555, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (AA 120-241) antibody (ABIN968620) Western blot analysis of Ufd1L on a mouse macrophage cell lysate. Lane 1: 1:1000, lan...
Immunofluorescence (IF) image for anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (AA 120-241) antibody (ABIN968620) Immunofluorescence staining of NIH/3T3 cells (Mouse embryo fibroblast cells, ATCC CRL...
 image for anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (AA 120-241) antibody (ABIN968620) anti-Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L) (AA 120-241) antibody (Image 3)
Product cited in: Nagahama, Suzuki, Hamada et al.: "SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 262-73, 2003 (PubMed).

Meyer, Shorter, Seemann et al.: "A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways." in: The EMBO journal, Vol. 19, Issue 10, pp. 2181-92, 2000 (PubMed).

Yamagishi, Garg, Matsuoka et al.: "A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects." in: Science (New York, N.Y.), Vol. 283, Issue 5405, pp. 1158-61, 1999 (PubMed).

Pizzuti, Novelli, Ratti et al.: "UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome." in: Human molecular genetics, Vol. 6, Issue 2, pp. 259-65, 1997 (PubMed).

Catalog No. ABIN968620
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