ADIPOQ antibody (AA 1-247)

Catalog No. ABIN968621

Product Details anti-ADIPOQ Antibody

Target: ADIPOQ (Adiponectin (ADIPOQ))

Binding Specificity: AA 1-247

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ADIPOQ antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Acrp30 aa. 1-247

Clone: 31-Acrp30

Isotype: IgG2a

Application Details

Comment:

Related Products: ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-ADIPOQ antibody (ABIN968621)

Bogan, Lodish: "Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4." in: The Journal of cell biology, Vol. 146, Issue 3, pp. 609-20, (1999) (PubMed).

Target Details for ADIPOQ

Target: ADIPOQ (Adiponectin (ADIPOQ))

Alternative Name: Acrp30 (ADIPOQ Products)

Synonyms: ADP antibody, DCAF9 antibody, 6720489L24Rik antibody, 9330209L04Rik antibody, Adp antibody, Mamdc1 antibody, RNSVSP4U antibody, SVSIV1 antibody, Svp4 antibody, ACDC antibody, ACRP30 antibody, ADIPQTL1 antibody, ADPN antibody, APM-1 antibody, APM1 antibody, GBP28 antibody, apM-1 antibody, 30kDa antibody, APN antibody, Acdc antibody, Acrp30 antibody, Ad antibody, adipo antibody, apM1 antibody, ADN antibody, acrpl antibody, adipo-b antibody, adipoql antibody, zgc:153584 antibody, adipoq antibody, WD and tetratricopeptide repeats 1 antibody, MAM domain containing glycosylphosphatidylinositol anchor 2 antibody, seminal vesicle secretory protein 4 antibody, adiponectin, C1Q and collagen domain containing antibody, adiponectin, C1Q and collagen domain containing, b antibody, adiponectin, C1Q and collagen domain containing L homeolog antibody, WDTC1 antibody, Mdga2 antibody, Svs4 antibody, ADIPOQ antibody, Adipoq antibody, adipoqb antibody, adipoq.L antibody

Background: Adipocytes express a variety of proteins that function in the homeostatic control of glucose and lipid metabolism. Insulin regulates the translocation and secretion of many of these adipocyte proteins in response to homeostatic changes in energy balance. Both adipsin and adipocyte complement-related protein of 30 kDa (Acrp30) are secretory proteins whose secretion from adipocytes is enhanced by insulin stimulation. Acrp30 contains N-terminal collagen repeats and a globular C-terminal domain. It is homologous to collagen type VIII and X and to complement factor C1q. Also, it forms homo-oligomeric structures of 90 and 300 kDa. The expression of Acrp30 increases 100 fold during adipocyte differentiation and it is commonly found in serum. Insulin stimulation of 3T3-L1 fibroblasts leads to a 4-fold increase in Acrp30 secretion. This secretion is regulated by PI3-kinase activity and may involve a secretory pathway that is distinct from other insulin-regulated secretory pathways, such as that involved with the translocation of glucose transporters and transferrin receptors. Thus, Acrp30 is an adipocyte secretory protein that functions in the regulation of energy homeostasis.
Synonyms: Adiponectin

Molecular Weight: 30 kDa