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STAT6 antibody (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced) (pTyr641)

Details for Product anti-STAT6 Antibody No. ABIN968672, Supplier: Login to see New
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Synonyms D12S1644, IL-4-STAT, STAT6B, STAT6C
(83), (39), (27), (13), (13), (11), (10), (10), (6), (5), (5), (5), (5), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(309), (114), (97), (12), (8), (7), (6), (4), (2)
(261), (74), (4), (1)
This STAT6 antibody is un-conjugated
(10), (9), (8), (7), (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(235), (112), (85), (43), (38), (35), (33), (20), (16), (15), (6), (4), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Quantity 150 μg
Shipping to United States ( )
Isotype Ig
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from antiserum by negative adsorption and affinity chromatography.
Alternative Name Stat6 (STAT6 Antibody Abstract)
Background Interleukin-4 (IL-4), a major immunoregulatory cytokine, is secreted by activated T lymphocytes, basophils, and mast cells and plays an important role in modulating T helper cell lineage development. It induces specific gene expression via the tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). Stat6, a member of the signal transducers and activators of transcription protein family, mediates signals for IL-4 and, possibly, IL-13. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. Following cytokine receptor ligation, Jak kinases are activated and phosphorylate the cytoplasmic tails of the oligomerized receptors. The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. Thus, Stat6 mediates the IL-4 signal and is essential for the proper development of adaptive immunity.
Molecular Weight 100 kDa
Research Area Signaling, Receptors, Inflammation
Pathways JAK-STAT Signaling
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
 image for anti-STAT6 antibody (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced) (pTyr641) (ABIN968672) Daudi were untreated (lane 1) or treated (lane 2) with IL-4. The top panel was probed...
 image for anti-STAT6 antibody (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced) (pTyr641) (ABIN968672) Eahy control (first panel) and Eahy IL-4 (second panel).
Product cited in: Mikita, Campbell, Wu et al.: "Requirements for interleukin-4-induced gene expression and functional characterization of Stat6." in: Molecular and cellular biology, Vol. 16, Issue 10, pp. 5811-20, 1996 (PubMed).

Hou, Schindler, Henzel et al.: "An interleukin-4-induced transcription factor: IL-4 Stat." in: Science (New York, N.Y.), Vol. 265, Issue 5179, pp. 1701-6, 1994 (PubMed).

Background publications Quelle, Shimoda, Thierfelder et al.: "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis." in: Molecular and cellular biology, Vol. 15, Issue 6, pp. 3336-43, 1995 (PubMed).

Catalog No. ABIN968672
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