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Details for Product No. ABIN968681

Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 144-262) antibody

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Antigen
Synonyms IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, NO, NOS-I, Nos-1, 2310005C01Rik, nos
Epitope
»Alternatives AA 144-262
Reactivity
»Alternatives Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN968681
Quantity 150 µg
Price
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Immunogen Rat nNOS/NOS Type I
Clone AA6
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name nNOS/NOS Type I
Background Nitric oxide synthase (NOS) is a cell-type specific enzyme which catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical which transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In neurons and endothelial cells, constitutive NOS (cNOS) is activated by agonists that increase intracellular Ca2+concentrations and enhance calmodulin binding. Neuronal NOS (nNOS or bNOS) and endothelial NOS (eNOS) have recognition sites for NADPH, FAD, FMN, and calmodulin and are regulated in a similar manner. However, both have been shown to be distinct gene products of about 155kDa and 140kDa, respectively, and the human forms show 52% amino acid identity to each other. nNOS and the 130 kDa inducible macrophage NOS (iNOS) share 51% amino acid homology. nNOS (neuronal NOS) is found in the cytoplasm of cell types such as neurons, skeletal muscle fibers, and lung epithelium. It is slightly larger than the other isoforms due to an N-terminal extension containing a PDZ domain through which it binds PSD-95 (post-synaptic density protein) and localizes to the cell membrane of synapses.
Molecular Weight 155 kDa
Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Nathan: "Nitric oxide as a secretory product of mammalian cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 6, Issue 12, pp. 3051-64, 1992 (PubMed).

Bredt, Hwang, Glatt et al.: "Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase." in: Nature, Vol. 351, Issue 6329, pp. 714-8, 1991 (PubMed).

Tochio, Mok, Zhang et al.: "Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain." in: Journal of molecular biology, Vol. 303, Issue 3, pp. 359-70, 2000 (PubMed).

Alternatives for antigen "Nitric Oxide Synthase 1, Neuronal (NOS1)", type "Antibodies"
Hosts (117), (15), (11), (3), (3)
Reactivities (114), (92), (62), (19), (17), (16), (12), (7), (4), (3), (2), (2)
Applications (98), (50), (33), (30), (27), (22), (20), (12), (10), (8), (4), (4), (4)
Conjugates (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (22), (7), (6), (6), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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