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Details for Product No. ABIN968684

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) (AA 348-464) antibody

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Antigen
Synonyms A-116A10.1, APPBP1, ula-1, Appbp1, 59kDa, CG7828, Dmel\\CG7828, anon-WO0140519.225, dAPP-BP1, dAPPBP1
Epitope
»Alternatives AA 348-464
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN968684
Quantity 50 µg
Price
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Immunogen Human APP-BP1
Clone LEP-02
Isotype IgG2a
Cross-Reactivity Mouse (Murine), Dog (Canine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name APP-BP1
Background Amyloid precursor protein (APP) gene encodes multiple APPs ranging from 695 to 770 amino acids. These proteins are processed into beta-Amyloid peptides (39-43 amino acids), which form abnormal plaques in the cerebral cortex and blood vessel walls during Alzheimer’s disease. The transmembrane form of APP is a putative cell surface receptor that possesses neurite-promoting activity, co-localizes with the plaques found in Alzheimer’s disease, and is involved in synaptic vesicle recycling. APP binding protein 1 (APP-BP1) interacts with the C-terminus of APP, and is a relative of the ubiquitin-activating enzymes (E1). The structure of APP-BP1 includes a human Uba3 binding site (UBS) at amino acids 443 to 479. This site may be important for APP-BP1 regulation of the cell cycle through interactions with ubiquitinylation-related pathways. Transfection of APP-BP1 in cells with a ts41 mutation suppresses the abnormal S-phases observed in these cells in a hUba3- and hUbc12-dependent manner. In addition, APP-BP1 has been implicated in ubiquitinylation-dependent apoptosis in neurons. Thus, APP-BP1 may be a multi-functional APP-binding protein that regulates cell cycle dynamics.
Synonyms: Amyloid Precursor Protein-Binding Protein 1
Molecular Weight 59 kDa
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Chow, Korenberg, Chen et al.: "APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein." in: The Journal of biological chemistry, Vol. 271, Issue 19, pp. 11339-46, 1996 (PubMed).

Hori, Osaka, Chiba et al.: "Covalent modification of all members of human cullin family proteins by NEDD8." in: Oncogene, Vol. 18, Issue 48, pp. 6829-34, 2000 (PubMed).

Chen, McPhie, Hirschberg et al.: "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons." in: The Journal of biological chemistry, Vol. 275, Issue 12, pp. 8929-35, 2000 (PubMed).

Alternatives for antigen "NEDD8 Activating Enzyme E1 Subunit 1 (NAE1)", type "Antibodies"
Hosts (32), (6)
Reactivities (37), (16), (15), (12), (12)
Applications (29), (15), (10), (10), (7), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (4), (2), (2), (2), (2), (1), (1), (1)
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