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MAPK8IP1 antibody (AA 180-384)

MAPK8IP1 Reactivity: Rat, Mouse WB, FM Host: Mouse Monoclonal 50-JIP unconjugated
Catalog No. ABIN968696
  • Target See all MAPK8IP1 Antibodies
    MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))
    Binding Specificity
    • 15
    • 10
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 180-384
    Reactivity
    • 50
    • 30
    • 17
    Rat, Mouse
    Host
    • 49
    • 1
    • 1
    Mouse
    Clonality
    • 51
    Monoclonal
    Conjugate
    • 20
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAPK8IP1 antibody is un-conjugated
    Application
    • 44
    • 24
    • 13
    • 13
    • 9
    • 8
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Fluorescence Microscopy (FM)
    Cross-Reactivity
    Rat (Rattus)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Please refer to us for technical protocols.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse JIP-1 aa. 180-384
    Clone
    50-JIP
    Isotype
    IgG1
    Top Product
    Discover our top product MAPK8IP1 Primary Antibody
  • Comment

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Meyer, Liu, Margolis: "Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons." in: The Journal of biological chemistry, Vol. 274, Issue 49, pp. 35113-8, (2000) (PubMed).

    Bonny, Nicod, Waeber: "IB1, a JIP-1-related nuclear protein present in insulin-secreting cells." in: The Journal of biological chemistry, Vol. 273, Issue 4, pp. 1843-6, (1998) (PubMed).

    Dickens, Rogers, Cavanagh, Raitano, Xia, Halpern, Greenberg, Sawyers, Davis: "A cytoplasmic inhibitor of the JNK signal transduction pathway." in: Science (New York, N.Y.), Vol. 277, Issue 5326, pp. 693-6, (1997) (PubMed).

  • Target
    MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))
    Alternative Name
    JIP-1 (MAPK8IP1 Products)
    Synonyms
    IB1 antibody, JIP-1 antibody, Jip1 antibody, Prkm8ip antibody, Skip antibody, mjip-2a antibody, JIP1 antibody, Jip-1 antibody, Mapk8ip antibody, PRKM8IP antibody, mitogen-activated protein kinase 8 interacting protein 1 antibody, MAPK8IP1 antibody, Mapk8ip1 antibody
    Background
    The JNK group of MAPKs is activated by a variety of inflammatory cytokines and environmental stressors. Activated JNK phosphorylates many cellular proteins, such as components of the AP-1 transcription factor complex (c-Jun and ATF-2). JNK-interacting proteins (JIPs) bind JNK, MKK7, MLKs, p190RhoGEF, and the Ste20-related protein kinase HPK1. In mouse, alternative splicing of JIP produces multiple splice variants, JIP-1, JIP-1b, JIP-2a, JIP-2b, and JIP-3. The structure of full length JIP consists of two N-terminal acidic regions, a JNK binding domain (JBD), two proline rich regions (PR), and both an SH3 and a phosphotyrosine-binding domain in the C-terminal region. JIP-1 localizes to the tips of neurites in differentiated PC12 cells, and may interact with JNK, MKK7, and MLK to facilitate formation of the JNK activating complex. IB1 is the rat homologue of JIP-1b, a JIP-1 variant that includes a 47 amino acid insert in the C-terminal region. IB1 is found in the nucleus and cytoplasm, and may function as a transactivator of the GLUT2 gene. Thus, JIP-1 and its related isoforms may have multiple functions that involve specific protein-protein interactions.
    Synonyms: JNK Interacting Protein
    Molecular Weight
    112 kDa
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