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TREX1 antibody (AA 82-179)

TREX1 Reactivity: Mouse WB, IF Host: Mouse Monoclonal 29-TREX1 unconjugated
Catalog No. ABIN968709
  • Target See all TREX1 Antibodies
    TREX1 (three Prime Repair Exonuclease 1 (TREX1))
    Binding Specificity
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 82-179
    Reactivity
    • 37
    • 5
    • 5
    Mouse
    Host
    • 30
    • 7
    Mouse
    Clonality
    • 24
    • 13
    Monoclonal
    Conjugate
    • 22
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This TREX1 antibody is un-conjugated
    Application
    • 23
    • 9
    • 6
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse TREX1 aa. 82-179
    Clone
    29-TREX1
    Isotype
    IgG1
    Top Product
    Discover our top product TREX1 Primary Antibody
  • Comment

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Höss, Robins, Naven, Pappin, Sgouros, Lindahl: "A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein." in: The EMBO journal, Vol. 18, Issue 13, pp. 3868-75, (1999) (PubMed).

    Mazur, Perrino: "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 19655-60, (1999) (PubMed).

  • Target
    TREX1 (three Prime Repair Exonuclease 1 (TREX1))
    Alternative Name
    TREX1 (TREX1 Products)
    Synonyms
    AGS1 antibody, CRV antibody, DRN3 antibody, HERNS antibody, 1661 antibody, AU041952 antibody, RGD1309596 antibody, three prime repair exonuclease 1 antibody, CpipJ_CPIJ012074 antibody, Tsp_03749 antibody, TREX1 antibody, Trex1 antibody
    Background
    DNA replication, repair, and recombination requires the excision of nucleotides from the DNA 3' termini. Many 3' to 5' exonucleases have been identified which catalyze the excision of monophosphates from the 3' termini of DNA. TREX1 and TREX2 are 3' to 5' exonucleases that contain three conserved exonuclease active site motifs (EASM) that may produce exonuclease activity. TREX1 and TREX2 are most closely related to the proofreading exonucleases of the bacterial replicative DNA polymerases and the RNase T enzymes. Recombinant expression of TREX1 and TREX2 demonstrates that they have exonuclease activity when oligonucleotide is present. TREX1 shows the greatest exonuclease activity with partial duplex DNA, and no activity with single-stranded RNA or an RNA-DNA partial duplex. In addition, reconstitution of TREX1 with DNA polymerase beta and DNA ligase III-XRCC1 facilitates accurate rejoining of a 3' mismatched base residue at a single-strand break. Thus, TREX1 and TREX2 are 3' to 5' exonucleases that may be important for excision of nucleotides during DNA replication, repair, and recombination.
    Molecular Weight
    32 kDa
    Pathways
    Apoptosis
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