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SERPINE1 antibody (serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1) (AA 207-329)

Details for Product anti-SERPINE1 Antibody No. ABIN968718, Supplier: Log in to see
Antigen
  • PAI
  • PAI-1
  • PAI1
  • PLANH1
  • si:ch211-138a11.1
  • SERPINE1
  • Planh1
  • B230326M24Rik
  • PI-7
  • PI7
  • PN-1
  • Spi4
  • HsT1201
  • PAI-2
  • PAI2
  • PLANH2
  • PAI1A
  • Pai1
  • Pai1aa
  • Planh
  • RATPAI1A
Alternatives
anti-Human SERPINE1 antibody for ELISA
Epitope
AA 207-329
24
13
13
12
11
7
5
5
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
312
98
92
30
11
8
2
2
2
1
1
1
1
Host
Mouse
223
111
49
28
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This SERPINE1 antibody is un-conjugated
41
28
16
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunofluorescence (IF), Western Blotting (WB)
277
200
87
48
43
28
23
21
19
16
9
6
6
6
6
4
4
4
4
4
2
1
1
1
1
Supplier
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Immunogen Human PAI-1 aa. 207-329
Clone 41-PAI
Isotype IgG1
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name PAI-1 (SERPINE1 Antibody Abstract)
Background Fibrinolysis is regulated by the plasminogen activators, tissue plasminogen activator (tPA) and urokinase PA (uPA), and by the plasminogen activator-inhibitors (PAIs). Two PAIs include the serpin family members, PAI-1 and PAI-2. PAI-1 is a glycoprotein found in plasma, platelets, endothelial cells, hepatoma cells, and fibrosarcoma cells. Thrombin, endotoxin, and IL-1 induce PAI-1 synthesis in endothelial cells, which is where the major portion of plasma PAI-1 is produced. PAI-2 is a glycoprotein expressed in placenta and monocyte macrophages. The uPA/plasmin system may play a key role in cancer progression through degradation of the extracellular matrix during tumor cell migration. Paradoxically, high levels of PAI-1 are also predictive of poor prognosis of cancer patients. This finding may be a result of the role of plasmin proteolysis in the prevention of tumor vessel assembly. PAI-1 can promote tumor angiogenesis, and the mechanism may involve PAI-induced regulation of plasmin proteolysis during tumor angiogenesis. Thus, PAI-1 is a serpin protease inhibitor that is important for the regulation of plasmin proteolysis during fibrinolysis and extracellular matrix degradation.
Molecular Weight 47 kDa
Pathways p53 Signaling
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-SERPINE1 antibody (serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1) (AA 207-329) (ABIN968718) Western blot analysis of PAI-1 on human endothelial cell lysate. Lane 1: 1:2500, lane...
Product cited in: Cai, Li, Goette et al.: "Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke." in: Circulation, Vol. 106, Issue 22, pp. 2854-8, 2002 (PubMed).

Bajou, Masson, Gerard et al.: "The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies." in: The Journal of cell biology, Vol. 152, Issue 4, pp. 777-84, 2001 (PubMed).

Ginsburg, Zeheb, Yang et al.: "cDNA cloning of human plasminogen activator-inhibitor from endothelial cells." in: The Journal of clinical investigation, Vol. 78, Issue 6, pp. 1673-80, 1986 (PubMed).

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