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Cullin 1 antibody (CUL1) (AA 56-246)

Details for Product anti-CUL1 Antibody No. ABIN968721, Supplier: Login to see New
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Synonyms LOC100282292, Cul1, zgc:55747, zgc:77500, wu:fc13a10, CUL1, cullin-1, Cullin-1, ATCUL1, AUXIN RESISTANT 6, AXR6, T10P11.26, T10P11_26, cullin 1, cul1, wu:fi43h07, wu:fj43a08, zgc:111899, zgc:55483
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AA 56-246
(49), (16), (5), (4), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(122), (45), (32), (4), (4), (3), (3), (2), (2), (1), (1), (1)
(116), (5), (1)
Clonality (Clone)
Monoclonal ()
This Cullin 1 antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(98), (48), (41), (26), (21), (18), (11), (6), (3), (2), (1), (1), (1)
Pubmed 3 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Mouse CUL-1 aa. 56-246
Clone 19-CUL
Isotype IgG1
Cross-Reactivity Human, Rat (Rattus), Dog (Canine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CUL-1 (CUL1 Antibody Abstract)
Background The cullins are a family of proteins that are integral to cell cycle regulation. Members of this family include human Cul proteins, C.elegans Ce-Cul-1, and S. cerevisiae Cdc53. Proper control of cell cycle progression is essential for the prevention of tumorigenesis. Mutant forms of both Ce-Cul-1 and Cdc53 have been implicated in the oncogenic process. The human Cul family of proteins, Cul-1, -2, -3, -4A, -4B, and -5, have also been implicated in oncogenic processes. Abnormal nuclear localization of Cul-2 is seen in the VHL (von Hippel-Lindau) syndrome, which includes development of a variety of cancers. Cul-3 is widely expressed in normal cells, and has increased expression in colon cancer cells. Cul-3 can associate with cyclin E in mammalian cells, and overexpression of Cul-3 targets cyclin E for ubiquination. Cul-1 associates with the ubiquination-conjugating complex, cyclin A/CDC34/p45[SKP2]/p19[SKP1]. In addition, Cul-1 interacts with p19[SKP1], E2 ubiquination-conjugating enzyme, and FWD1 to facilitate ubiquitin degradation of IkappaBalpha, beta.catenin, and Vpu proteins. Thus, Cul-1, as well as other cullin family members, may have important roles in cycle-dependent ubiquitin degradation.
Molecular Weight 90 kDa
Pathways Cell Division Cycle, Hedgehog Signaling

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Cullin 1 antibody (CUL1) (AA 56-246) (ABIN968721) Western blot analysis of CUL-1 on a P19 cell lysate (Mouse embryonal carcinoma, ATCC ...
Product cited in: Hatakeyama, Kitagawa, Nakayama et al.: "Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3859-63, 1999 (PubMed).

Lisztwan, Marti, Sutterlüty et al.: "Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway." in: The EMBO journal, Vol. 17, Issue 2, pp. 368-83, 1998 (PubMed).

Kipreos, Lander, Wing et al.: "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family." in: Cell, Vol. 85, Issue 6, pp. 829-39, 1996 (PubMed).

Catalog No. ABIN968721
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