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Cullin 1 (CUL1) (AA 56-246) antibody

Details for Product No. ABIN968721
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Antigen
Synonyms cullin-1, Cullin-1, ATCUL1, AUXIN RESISTANT 6, AXR6, T10P11.26, T10P11_26, cullin 1, LOC100282292, Cul1, zgc:55747, zgc:77500, wu:fc13a10, CUL1
Epitope
AA 56-246
(31), (8), (3), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(84), (38), (22), (12), (12), (1), (1), (1), (1)
Host
Mouse
(80), (5), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(68), (34), (26), (24), (21), (14), (10), (5), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 50 µg
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Catalog No. ABIN968721
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Immunogen Mouse CUL-1
Clone Hs-3
Isotype IgG1
Cross-Reactivity Human, Rat (Rattus), Dog (Canine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name CUL-1
Background The cullins are a family of proteins that are integral to cell cycle regulation. Members of this family include human Cul proteins, C.elegans Ce-Cul-1, and S. cerevisiae Cdc53. Proper control of cell cycle progression is essential for the prevention of tumorigenesis. Mutant forms of both Ce-Cul-1 and Cdc53 have been implicated in the oncogenic process. The human Cul family of proteins, Cul-1, -2, -3, -4A, -4B, and -5, have also been implicated in oncogenic processes. Abnormal nuclear localization of Cul-2 is seen in the VHL (von Hippel-Lindau) syndrome, which includes development of a variety of cancers. Cul-3 is widely expressed in normal cells, and has increased expression in colon cancer cells. Cul-3 can associate with cyclin E in mammalian cells, and overexpression of Cul-3 targets cyclin E for ubiquination. Cul-1 associates with the ubiquination-conjugating complex, cyclin A/CDC34/p45[SKP2]/p19[SKP1]. In addition, Cul-1 interacts with p19[SKP1], E2 ubiquination-conjugating enzyme, and FWD1 to facilitate ubiquitin degradation of IkappaBalpha, beta.catenin, and Vpu proteins. Thus, Cul-1, as well as other cullin family members, may have important roles in cycle-dependent ubiquitin degradation.
Molecular Weight 90 kDa
Comment

Related Products: ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Cullin 1 (CUL1) (AA 56-246) antibody Western blot analysis of CUL-1 on a P19 cell lysate (Mouse embryonal carcinoma, ATCC CRL-1825) . Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti- CUL-1 antibody.
Product cited in: Kipreos, Lander, Wing et al.: "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family." in: Cell, Vol. 85, Issue 6, pp. 829-39, 1996 (PubMed).

Lisztwan, Marti, Sutterlüty et al.: "Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway." in: The EMBO journal, Vol. 17, Issue 2, pp. 368-83, 1998 (PubMed).

Hatakeyama, Kitagawa, Nakayama et al.: "Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3859-63, 1999 (PubMed).

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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN968721
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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