SRR antibody (AA 127-248)

Catalog No. ABIN968727

Product Details anti-SRR Antibody

Target: SRR (Serine Racemase (SRR))

Binding Specificity: AA 127-248

Reactivity: Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This SRR antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Rat (Rattus)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse serine racemase aa. 127-248

Clone: 29-Serine Racemase

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN968540, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20° C.

References for anti-SRR antibody (ABIN968727)

Mothet, Parent, Wolosker, Brady, Linden, Ferris, Rogawski, Snyder: "D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 9, pp. 4926-31, (2000) (PubMed).

Wolosker, Blackshaw, Snyder: "Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 23, pp. 13409-14, (1999) (PubMed).

Target Details for SRR

Target: SRR (Serine Racemase (SRR))

Alternative Name: Serine Racemase (SRR Products)

Synonyms: DDBDRAFT_0188432 antibody, DDBDRAFT_0230209 antibody, DDB_0188432 antibody, DDB_0230209 antibody, ilv1 antibody, iso1 antibody, ILV1 antibody, ISO1 antibody, Srs antibody, serine racemase antibody, Serine racemase antibody, SRR antibody, srr antibody, NGR_b19540 antibody, ZPR_3642 antibody, MGYG_07950 antibody, Halhy_2637 antibody, Runsl_3290 antibody, Srr antibody

Background: The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. NMDA receptors require coactivation at both glutamate and glycine sites. D-serine is a D-amino acid found in mammalian tissues that can act as a potent ligand for the glycine site on NMDA receptors. D-serine is made by the enzyme serine racemase, which is a member of the pyridoxal-5' phosphate (PLP)-dependent enzyme family. Serine racemase mRNA is expressed in brain and liver, and serine racemase protein is expressed in glial cells. Degradation of D-serine by D-amino acid oxidase attenuates NMDA receptor-mediated calcium influx, and implicates D-serine as an endogenouse modulator of NMDA receptor function. Thus, glial cell production of D-serine via serine racemase activity may be an important system for modulation of synaptic transmission. This antibody is routinely tested by western blot analysis.

Molecular Weight: 38 kDa