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TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) (AA 454-565) antibody

Details for Product No. ABIN968728
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Antigen
Synonyms
TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135, CG5444, Dmel\\CG5444, SR3-3, SY3-2 TAF110, TAF, TAF110, TAF4, TAFII110, TAF[II]110, TAF[[II]], TAF[[II]]110, TFIID, TFIID 110, Taf110, Taf[[II]]110, d110, dTA ... show more
TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135, CG5444, Dmel\\CG5444, SR3-3, SY3-2 TAF110, TAF, TAF110, TAF4, TAFII110, TAF[II]110, TAF[[II]], TAF[[II]]110, TFIID, TFIID 110, Taf110, Taf[[II]]110, d110, dTAF4, dTAFII110, dTAF[[II]]110, dmTAF4, l(3)72Dj, p110, taf110 show less
Epitope
AA 454-565
(2), (1), (1), (1)
Reactivity
Human
(18), (11), (1), (1), (1), (1), (1), (1)
Host
Mouse
(13), (6)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB), Immunofluorescence (IF)
(16), (8), (2), (1), (1)
Pubmed 4 references available
Quantity 50 µg
Options
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Catalog No. ABIN968728
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Immunogen Human TAF[II]135
Clone LPR-02
Isotype IgG1
Cross-Reactivity Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name TAF II135
Background Tightly associated factors (TAFs) play an essential role in transcriptional activation through their interaction with a variety of activators. TAF[II]135 (a.k.a. TAF[II]130) is a human homologue of Drosophila TAF[II]110, the first TAF shown to have coactivator activity. TAF[II]135 contains multiple glutamine-rich regions, as well as a coactivator domain (CAD). The glutamine-rich regions of TAF[II]135 facilitate interaction with Sp1 and CREB, which leads to enhancement of both Sp1- and CREB-mediated transcription. In addition, TAF[II]135 can potentiate transcriptional stimulation by AF-2 of the retinoic acid, thyroid hormone, and vitamine D3 receptors. However, TAF[II]135 does not interact with the AF-2s of the estrogen and retinoid X receptors. Interestingly, TAF[II]135 enhancement of CREB transcriptional activity may be disrupted by expanded polyglutamine (CAG) repeats found in at least eight different neurodegenerative disorders. Thus, TAF[II]135 may have important coactivator activities in many different transcription-regulating cell signaling pathways, and interference of TAF[II]135 activity by CAG repeats may be a common mechanism of specific types of neuropathologies.
Molecular Weight 135 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) (AA 454-565) antibody Western blot analysis of TAF[II] 135 on Jurkat lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-TAF[II] 135.
anti-TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) (AA 454-565) antibody (2) Immunofluorescent staining of HeLa cells.
Product cited in: Mengus, May, Carré et al.: "Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells." in: Genes & development, Vol. 11, Issue 11, pp. 1381-95, 1997 (PubMed).

Saluja, Vassallo, Tanese: "Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators." in: Molecular and cellular biology, Vol. 18, Issue 10, pp. 5734-43, 1998 (PubMed).

Shimohata, Nakajima, Yamada et al.: "Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription." in: Nature genetics, Vol. 26, Issue 1, pp. 29-36, 2000 (PubMed).

Freiman, Albright, Chu et al.: "Redundant role of tissue-selective TAF(II)105 in B lymphocytes." in: Molecular and cellular biology, Vol. 22, Issue 18, pp. 6564-72, 2002 (PubMed).

Hosts (13), (6)
Reactivities (18), (11), (1), (1), (1), (1), (1), (1)
Applications (16), (8), (2), (1), (1)
Epitopes (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN968728
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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