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AMACR antibody (alpha-Methylacyl-CoA Racemase) (AA 139-229)

Details for Product anti-AMACR Antibody No. ABIN968731, Supplier: Log in to see
Antigen
  • AMACR
  • amacr
  • AMACRD
  • CBAS4
  • Da1-8
  • DKFZp469O1232
  • Macr1
  • Marc1
  • MGC89832
  • NCU04099.1
  • RACE
  • RM
Epitope
AA 139-229
28
10
9
5
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
152
36
34
Host
Mouse
106
44
2
Clonality (Clone)
Monoclonal ()
Conjugate
This AMACR antibody is un-conjugated
6
5
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
109
74
53
31
23
19
15
11
10
6
4
4
2
1
Supplier
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Immunogen Human alpha-Methylacyl-CoA Racemase
Clone Ghr5
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name alpha-Methylacyl-CoA Racemase (AMACR Antibody Abstract)
Background Alpha-methylacyl-CoA Racemase (AMACR) catalyzes the racemization of alpha-methyl-branched carboxylic acid coenzyme A thioesters. This enzymatic function is involved with biosynthesis of bile acids in the mitochondria and peroxisomes. AMACR converts pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers, which are the only stereoisomers degraded by peroxisomal alpha-oxidation. Interestingly, AMACR mutations have been linked to some sensory motor neuropathies where accumulation of fatty acids and AMACR deficiencies correlate with pathogenesis. AMACR contains an N-terminal region required for mitochondrial localization, and a C-terminal peroxisomal targeting signal type 1 (PTS). AMACR mRNA is expressed preferentially in human, rat, and mouse liver and kidney, but the percentage of AMACR enzymatic activity found in the mitochondria relative to the peroxisomes differs depending on the species. Thus, AMACR is an enzyme critical for fatty acid degradation, and bile formation.
Molecular Weight 42 kDa
Comment

Related Products: ABIN968543, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Western Blotting (WB) image for anti-AMACR antibody (alpha-Methylacyl-CoA Racemase) (AA 139-229) (ABIN968731) Western blot analysis of alpha-Methylacyl-CoA Racemase on a mouse liver lysate. Lane ...
Product cited in: Ferdinandusse, Denis, Clayton, Graham, Rees, Allen, McLean, Brown, Vreken, Waterham, Wanders: "Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy." in: Nature genetics, Vol. 24, Issue 2, pp. 188-91, 2000 (PubMed).

Kotti, Savolainen, Helander, Yagi, Novikov, Kalkkinen, Conzelmann, Hiltunen, Schmitz: "In mouse alpha -methylacyl-CoA racemase, the same gene product is simultaneously located in mitochondria and peroxisomes." in: The Journal of biological chemistry, Vol. 275, Issue 27, pp. 20887-95, 2000 (PubMed).