alpha-Methylacyl-CoA Racemase (AMACR) (AA 139-229) antibody

Details for Product No. ABIN968731
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Synonyms AMACR, DKFZp469O1232, amacr, NCU04099.1, MGC89832, AMACRD, CBAS4, RACE, RM, Macr1, Da1-8, Marc1
AA 139-229
(23), (15), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(124), (28), (25)
(99), (25)
Clonality (Clone)
Monoclonal ()
(6), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(93), (65), (36), (28), (19), (14), (13), (10), (9), (4), (3), (2), (2), (2), (1)
Pubmed 2 references available
Quantity 50 μg
Shipping to United States (Change)
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Catalog No. ABIN968731
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Immunogen Human alpha-Methylacyl-CoA Racemase
Clone Ghr5
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name alpha-Methylacyl-CoA Racemase
Background Alpha-methylacyl-CoA Racemase (AMACR) catalyzes the racemization of alpha-methyl-branched carboxylic acid coenzyme A thioesters. This enzymatic function is involved with biosynthesis of bile acids in the mitochondria and peroxisomes. AMACR converts pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers, which are the only stereoisomers degraded by peroxisomal alpha-oxidation. Interestingly, AMACR mutations have been linked to some sensory motor neuropathies where accumulation of fatty acids and AMACR deficiencies correlate with pathogenesis. AMACR contains an N-terminal region required for mitochondrial localization, and a C-terminal peroxisomal targeting signal type 1 (PTS). AMACR mRNA is expressed preferentially in human, rat, and mouse liver and kidney, but the percentage of AMACR enzymatic activity found in the mitochondria relative to the peroxisomes differs depending on the species. Thus, AMACR is an enzyme critical for fatty acid degradation, and bile formation.
Molecular Weight 42 kDa

Related Products: ABIN968543, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-alpha-Methylacyl-CoA Racemase (AMACR) (AA 139-229) antibody Western blot analysis of alpha-Methylacyl-CoA Racemase on a mouse liver lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti- alpha-Methylacyl-CoA Racemase antibody.
Product cited in: Kotti, Savolainen, Helander et al.: "In mouse alpha -methylacyl-CoA racemase, the same gene product is simultaneously located in mitochondria and peroxisomes." in: The Journal of biological chemistry, Vol. 275, Issue 27, pp. 20887-95, 2000 (PubMed).

Ferdinandusse, Denis, Clayton et al.: "Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy." in: Nature genetics, Vol. 24, Issue 2, pp. 188-91, 2000 (PubMed).

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