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Dystroglycan 1 (DAG1) (AA 655-767) antibody

Details for Product No. ABIN968735
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Antigen
Synonyms DG, Dp71, Dp427, D9Wsu13e
Epitope
AA 655-767
(13), (9), (7), (4), (3), (1), (1), (1), (1)
Reactivity
Human
(56), (31), (30), (24), (15), (14), (13), (12), (3), (1), (1), (1)
Host
Mouse
(43), (11), (4), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB)
(39), (28), (20), (13), (11), (3), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 150 µg
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Catalog No. ABIN968735
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Immunogen Human beta-Dystroglycan
Clone 56
Isotype IgG2a
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name beta-Dystroglycan
Background Formation of the neuromuscular junction (NMJ) requires interaction between specific extracellular matrix proteins, intracellular cytoskeletal elements, and clustering of specific neurotransmitter receptors. Dystroglycans, alpha-dystroglycan and beta-dystroglycan, are two members of the dystrophin-associated complex, an essential element of NMJs. These proteins are encoded by the same gene, but posttranslationally cleaved to produce a 156 kDa extracellular peripheral membrane protein, alpha-dystroglycan, and a 43 kDa transmembrane protein, beta-dystroglycan. Dystroglycans are expressed highest in heart and muscle, but are also found in non-muscle tissues. alpha-dystroglycan may interact with agrin to facilitate AChR clustering at NMJs, and has been implicated as a laminin receptor. beta-dystroglycan recruits dystrophin to the sarcolemma, and interactions between beta-dystroglycan and caveolin-3 may regulate this recruitment. Mice deficient in dystroglycans have severly disorganized NMJs, and have reductions in the concentration of laminin, perlecan, and AChE at the synaptic basement membrane of NMJs. Thus, dystroglycans may have important extracellular and intracellular roles during NMJ assembly.
Molecular Weight 43-50 kDa
Comment

Related Products: ABIN968587, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Dystroglycan 1 (DAG1) (AA 655-767) antibody Western blot analysis of beta-Dystroglycan on a HepG2 cell lysate (Human hepatocellular carcinoma, ATCC HB-8065). Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the mouse anti-human beta-Dystroglycan antibody.
Product cited in: Ibraghimov-Beskrovnaya, Milatovich, Ozcelik et al.: "Human dystroglycan: skeletal muscle cDNA, genomic structure, origin of tissue specific isoforms and chromosomal localization." in: Human molecular genetics, Vol. 2, Issue 10, pp. 1651-7, 1994 (PubMed).

Sotgia, Lee, Das et al.: "Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members." in: The Journal of biological chemistry, Vol. 275, Issue 48, pp. 38048-58, 2000 (PubMed).

Jacobson, Côté, Rossi et al.: "The dystroglycan complex is necessary for stabilization of acetylcholine receptor clusters at neuromuscular junctions and formation of the synaptic basement membrane." in: The Journal of cell biology, Vol. 152, Issue 3, pp. 435-50, 2001 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN968735
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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