REST Corepressor 1 (RCOR1) (AA 78-192) antibody

Details for Product No. ABIN968756
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Antigen
Synonyms RCOR1, im:6904264, si:dkey-46n18.7, zgc:158607, COREST, RCOR, 5730409O11, 6720480E22Rik, AU042633, D12Wsu95e, mKIAA0071, rcor1, xcoREST
Epitope
AA 78-192
(21), (8), (7), (5), (1), (1), (1), (1)
Reactivity
Human
(39), (8), (4), (2), (1), (1)
Host
Mouse
(20), (19), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(39), (22), (21), (21), (7), (6), (2), (1)
Pubmed 3 references available
Quantity 50 μg
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Catalog No. ABIN968756
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Immunogen Human CoREST
Clone MK-1-25
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name CoRest
Background Histone deacetylases (HDACs) are found in large, multisubunit complexes. HDAC1 and HDAC2 are found predominately in either an mSin3A-containing complex or a complex containing the ATP-dependent chromatin remodeling protein, CHD4. The mSin3A complex is recrutied by DNA-binding transcription factors, such as the unligand hormone receptors. In these situations, the HDAC/mSin3A complex is thought to be involved in gene repression. CoREST is a corepressor for REST (RE1 silencing transcription factor) that is found in complex with mSin3A, as well as in non-mSin3A HDAC complexes. CoREST contains an N-terminal and a C-terminal SANT domain, which is common to corepressors involved in steroid horomone receptor gene repression. In non-neuronal cells, CoREST and REST mediate repression of the type II sodium channel promoter. REST is usually found in complex with mSin3A, and under certain conditions may recruit CoREST for repressor activity. The N-terminal SANT domain of CoREST is required for interaction with HDAC1 to form an HDAC complex that does not contain mSin3A or REST. Thus, CoREST is a corepressor that may interact with distinct protein complexes depending on the target for gene repression. This antibody is routinely tested by western blot analysis.
Molecular Weight 66 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-REST Corepressor 1 (RCOR1) (AA 78-192) antibody Immunofluorescence staining of PSFK-1 cells, a human primitive neuroectodermal tumor line.
anti-REST Corepressor 1 (RCOR1) (AA 78-192) antibody (2) Western blot analysis of CoREST on a Jurkat lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti- CoREST antibody.
Product cited in: Andrés, Burger, Peral-Rubio et al.: "CoREST: a functional corepressor required for regulation of neural-specific gene expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 17, pp. 9873-8, 1999 (PubMed).

Grimes, Nielsen, Battaglioli et al.: "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex." in: The Journal of biological chemistry, Vol. 275, Issue 13, pp. 9461-7, 2000 (PubMed).

You, Tong, Grozinger et al.: "CoREST is an integral component of the CoREST- human histone deacetylase complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 4, pp. 1454-8, 2001 (PubMed).

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