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Matrix Metalloproteinase 4 (MMP4) (AA 592-695) antibody

Details for Product No. ABIN968761
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Antigen
Synonyms
MBII-26, MPHOSPH4, NF90, NFAR, 4F.1, cbtf122, ilf3, ilf3-A, ubp3, ubp4, xilf3, CBTF, DRBF, DRBP76, MMP4, MPP4, NF-AT-90, NF110, NF110b, NF90a, NF90b, NFAR-1, NFAR2, TCP110, TCP80, wu:fb37d07, wu:fb94b ... show more
MBII-26, MPHOSPH4, NF90, NFAR, 4F.1, cbtf122, ilf3, ilf3-A, ubp3, ubp4, xilf3, CBTF, DRBF, DRBP76, MMP4, MPP4, NF-AT-90, NF110, NF110b, NF90a, NF90b, NFAR-1, NFAR2, TCP110, TCP80, wu:fb37d07, wu:fb94b02, zgc:77030 show less
Epitope
AA 592-695
(7), (6), (4), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(35), (14), (12), (3), (2), (2), (1)
Host
Mouse
(36), (1)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB), Immunofluorescence (IF)
(36), (16), (9), (5), (4), (2), (2)
Pubmed 4 references available
Quantity 50 µg
Options
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Catalog No. ABIN968761
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Immunogen Human DRBP76
Clone LPR-01
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name DRBP76
Background The double stranded RNA (dsRNA)-dependent, Ser/Thr protein kinase, PKR, is encoded by an IFN-inducible gene and is critical for the anti-viral responses mediated by IFN. Interaction with activators such as heparin, dsRNA, and the dsRNA-binding proteins (DRBPs), DRBP76, PACT, and RAX, induces PKR autophosphorylation and activation. DRBP76 was identified through its binding to dsRNA and PKR. In addition, DRBP76 has been identified as the alternatively spliced nuclear phosphoproteins of 90 kDa (NFAR-1/NF90) and 110 kDa (NFAR-2), as well as M-phase phosphoprotein (MPP4), translational control protein 80 (TCP80), and interleukin enhancer binding factor 3 (ILF3). DRBP76 contains a bi-partite nuclear localization signal at amino acids 369-373 and 386-394, two DRB domains in the C-terminal half, and a C-terminal RG2 domain that is present in many RNA binding proteins. DRBP76 binds pre-mRNAs and spliced mRNAs, co-localizes with PKR in the nucleus, and is phosphorylated by PKR and possibly cyclin-dependent kinases. Thus, DRBP76 may be one of multiple DRBP variants, which associate with PKR and regulate RNA translation. This antibody is routinely tested by western blot analysis.
Molecular Weight 90 kDa
Comment

Related Products: ABIN968535

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Matrix Metalloproteinase 4 (MMP4) (AA 592-695) antibody Western blot analysis of DRBP76 on HeLa lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of DRBP76.
anti-Matrix Metalloproteinase 4 (MMP4) (AA 592-695) antibody (2) Immunofluorescent staining of WI-38 cells at 50 µg/ml.
Product cited in: Buaas, Lee, Edelhoff et al.: "Cloning and characterization of the mouse interleukin enhancer binding factor 3 (Ilf3) homolog in a screen for RNA binding proteins." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 10, Issue 5, pp. 451-6, 1999 (PubMed).

Patel, Vestal, Xu et al.: "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR." in: The Journal of biological chemistry, Vol. 274, Issue 29, pp. 20432-7, 1999 (PubMed).

Xu, Grabowski: "Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs." in: Molecular genetics and metabolism, Vol. 68, Issue 4, pp. 441-54, 2000 (PubMed).

Saunders, Jurecic, Barber: "The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13." in: Genomics, Vol. 71, Issue 2, pp. 256-9, 2001 (PubMed).

Validation Images
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