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Details for Product No. ABIN968764

Leucine Rich Repeat (In FLII) Interacting Protein 1 (LRRFIP1) (AA 210-415) antibody

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Antigen
Synonyms FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP, Fliiap1, AU024550, hm:zeh1367, lrrfip1, wu:fc06b04, wu:fi15c07, zeh1367, LRRFIP1
Epitope
»Alternatives AA 210-415
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN968764
Quantity 150 µg
Price
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Immunogen Human GCF2
Clone TRAP-01
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name GCF2
Background Regulation of transcription is mediated by transcription factors that bind regulatory elements in gene promotors and enhancers, and alter the rate of transcription. Transcriptional repressors reduce transcription by their intrinsic repressor domain activity, or by binding to sites in the regulatory domain where a co-repressor can bind. GC-binding factors (GCF and GCF2) are transcriptional repressors that bind promoters with GC-rich sequences. GCF represses transcription of EGF, TGFalpha, and insulin-like growth factor II recepetors. GCF2 has some homology with GCF, and has also been identified as TRIP and LRRFIP1. The sequence of GCF2 includes an RNA binding domain (RBD), and N-glycosylation site, and a nuclear localization signal (NLS). GCF2 is widely expressed in many tissues and cells. GCF2 binds the EGFR and PDGFR promoters, and represses both EGFR and PDGFR transcription. In addition, GCF2 interacts with the leucine-rich repeat of flightless I, a protein that binds actin and contains a gelsolin-like domain. Thus, GCF2 may have functions in both RNA-cytoskeleton interactions, as well as roles in transcriptional repression. This antibody is routinely tested by western blot analysis.
Molecular Weight 160 kDa
Comment

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Wilson, Brown, Kingsman et al.: "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I." in: Nucleic acids research, Vol. 26, Issue 15, pp. 3460-7, 1998 (PubMed).

Reed, Yamazaki, Kaufman et al.: "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor." in: The Journal of biological chemistry, Vol. 273, Issue 34, pp. 21594-602, 1998 (PubMed).

Khachigian, Santiago, Rafty et al.: "GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury." in: Circulation research, Vol. 84, Issue 11, pp. 1258-67, 1999 (PubMed).

Alternatives for antigen "Leucine Rich Repeat (In FLII) Interacting Protein 1 (LRRFIP1)", type "Antibodies"
Hosts (34), (11)
Reactivities (44), (19), (14), (13), (13), (12), (1), (1), (1), (1)
Applications (36), (22), (10), (9), (6), (3), (2), (1), (1)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (4), (3), (3), (2), (2), (1), (1), (1)
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