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ARPC3 antibody (AA 10-118)

ARPC3 Reactivity: Human, Mouse, Rat, Dog, Chicken WB, IF Host: Mouse Monoclonal 26-p21 unconjugated
Catalog No. ABIN968781
  • Target See all ARPC3 Antibodies
    ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3))
    Binding Specificity
    • 16
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 10-118
    Reactivity
    • 41
    • 25
    • 18
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Dog, Chicken
    Host
    • 38
    • 2
    • 1
    Mouse
    Clonality
    • 39
    • 2
    Monoclonal
    Conjugate
    • 21
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ARPC3 antibody is un-conjugated
    Application
    • 37
    • 14
    • 13
    • 13
    • 13
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus), Chicken, Dog (Canine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human p21-Arc aa. 10-118
    Clone
    26-p21
    Isotype
    IgG1
    Top Product
    Discover our top product ARPC3 Primary Antibody
  • Comment

    Related Products: ABIN968535, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Zhao, Yang, Qian, Zhu: "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub." in: Biochemical and biophysical research communications, Vol. 280, Issue 2, pp. 513-7, (2001) (PubMed).

    Welch, DePace, Verma, Iwamatsu, Mitchison: "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly." in: The Journal of cell biology, Vol. 138, Issue 2, pp. 375-84, (1997) (PubMed).

  • Target
    ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa (ARPC3))
    Alternative Name
    p21-Arc (ARPC3 Products)
    Synonyms
    ARC21 antibody, p21-Arc antibody, 1110006A04Rik antibody, 21kDa antibody, AA408672 antibody, AI788639 antibody, p21-Ar antibody, p21Arc antibody, arc21 antibody, p21-arc antibody, zgc:86828 antibody, actin related protein 2/3 complex subunit 3 antibody, actin related protein 2/3 complex, subunit 3 antibody, actin related protein 2/3 complex subunit 3 L homeolog antibody, actin related protein 2/3 complex, subunit 3, 21kDa antibody, actin related protein 2/3 complex subunit 3 pseudogene antibody, actin-related protein 2/3 complex subunit 3 antibody, actin-related protein 2/3 complex subunit 3 pseudogene antibody, ARPC3 antibody, Arpc3 antibody, arpc3.L antibody, LOC738738 antibody, arpc3 antibody, LOC100036831 antibody, LOC100341254 antibody
    Background
    Cellular morphology, adhesion, and motility occur through the reorganization of the actin cytoskeleton. This reorganization of actin filaments occurs through the interactions between actin and actin binding proteins. Actin-binding proteins regulate the polymerization and depolymerization of actin, connect actin-based structures to membranes and to other cytoskeletal elements, power the movement of actin filaments, and cross-link actin filaments into bundles. Actin related proteins (Arp) 2/3 complex is an actin polymerization inducing complex that includes Arp2, Arp3, p41-Arc, p34-Arc, p21-Arc, p20 Arc, and p16-Arc. The Arp2 and Arp3 subunits may nucleate actin polymerization, while the p41-Arc subunit is a WD repeat-containing protein that may regulate both the activity and localization of the Arp2/3 complex. Arp3, p34-Arc, and p21-Arc are localized to the lamellipodia of stationary and locomoting fibroblasts. Both WASP and Abp1p are acidic sequence-containing proteins that activate the Arp2/3 complex. However, WASP binds actin monomers, while the endocytosis-related Abp1p protein binds actin filaments. Thus, Arp2/3 complex may regulate actin polymerization in specific cell locations through interaction with actin binding Arp2/3 activators.
    Molecular Weight
    21 kDa
    Pathways
    RTK Signaling, Regulation of Actin Filament Polymerization
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